Diagnostic accuracy of the Gaussian first‐trimester combined screening for pre‐eclampsia to predict small‐for‐gestational‐age neonates

Objective Pre‐eclampsia and delivery of small‐for‐gestational‐age (SGA) neonates can be predicted from the first trimester. A Gaussian model for prediction of PE has recently been described, although its capacity to predict SGA is still unknown. Methods This was a secondary analysis of a prospective...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2022-02, Vol.156 (2), p.322-330
Main Authors: Mendoza, Manel, Serrano, Berta, Bonacina, Erika, Capote, Sira, Garcia‐Manau, Pablo, Regincós, Laia, Murcia, Maria Teresa, Barberan, Lidia, Míguez, Marta, Carreras, Elena
Format: Article
Language:English
Subjects:
Biomarkers
Female
first trimester
Humans
Infant, Newborn
Infant, Small for Gestational Age
Placenta Growth Factor
placental growth factor
Pre-Eclampsia - diagnosis
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, First
pre‐eclampsia
Prospective Studies
Pulsatile Flow
screening
small for gestational age
Ultrasonography, Prenatal
Uterine Artery - diagnostic imaging
uterine artery Doppler
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Summary:Objective Pre‐eclampsia and delivery of small‐for‐gestational‐age (SGA) neonates can be predicted from the first trimester. A Gaussian model for prediction of PE has recently been described, although its capacity to predict SGA is still unknown. Methods This was a secondary analysis of a prospective cohort study conducted at Vall d’Hebron University Hospital (Barcelona) in 2483 single pregnancies from October 2015 to September 2017. Mean arterial blood pressure and mean uterine artery pulsatility index were recorded at the first‐trimester scan. Serum concentrations of placental growth factor and pregnancy‐associated plasma protein‐A were assessed between 8+0 and 13+6 weeks. The predictive capacities of early (
ISSN:0020-7292
1879-3479
DOI:10.1002/ijgo.13673