Cytomegalovirus optic neuropathy in a young immunocompetent patient

Cytomegalovirus (CMV) infection is common worldwide, but is usually a subclinical or self-limited infection in immunocompetent patients. On the contrary, most of the ocular and central nervous system involvement occurs in immunosuppressed patient, and usually has severe consequences. Ocular manifest...

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Bibliographic Details
Published in:Journal of neurovirology 2021-04, Vol.27 (2), p.364-366
Main Authors: Melancia, Diana, Fernandes, Andreia, Manita, Manuel, Cordeiro, Inês Menezes
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Case Report
Immunology
Infectious Diseases
Neurology
Neurosciences
Virology
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Summary:Cytomegalovirus (CMV) infection is common worldwide, but is usually a subclinical or self-limited infection in immunocompetent patients. On the contrary, most of the ocular and central nervous system involvement occurs in immunosuppressed patient, and usually has severe consequences. Ocular manifestations of CMV infection are frequent in immunosuppressed patients (notably keratouveitis, retinitis and retinal branch angiitis), but a few cases of optic neuropathy (mostly papillitis) have been reported in the literature in immunocompetent patients. We report a case of a young and previously healthy female patient who developed a CMV optic neuropathy after a presumed CMV reinfection. Viral copies were detected in both blood and cerebrospinal fluid, as well as a high IgG titre and no evidence of immunosuppression was found. Clinical improvement was seen after high-dose corticosteroids and ganciclovir.
ISSN:1355-0284
1538-2443
DOI:10.1007/s13365-021-00963-3