Usefulness of Serum Anti-p53 Antibody Measurement in Patients Undergoing Hepatectomy for Colorectal Liver Metastases

Background While anti-p53 antibody (p53-Ab) is a potential marker for early detection of colorectal cancer, its clinical utility in patients with advanced colorectal cancer remains unknown. Methods The clinical significance of p53-Ab was investigated by analyzing the data of 206 patients who underwe...

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Bibliographic Details
Published in:World journal of surgery 2021-06, Vol.45 (6), p.1906-1912
Main Authors: Kojima, Kazutaka, Shindoh, Junichi, Akabane, Miho, Umino, Ryosuke, Kobayashi, Yuta, Okubo, Satoshi, Hashimoto, Masaji
Format: Article
Language:English
Subjects:
Abdominal Surgery
Antibodies
Cancer
Cardiac Surgery
Colorectal cancer
Colorectal carcinoma
General Surgery
Hepatectomy
Liver
Medicine
Medicine & Public Health
Metastases
Metastasis
Multivariate analysis
Original Scientific Report
p53 Protein
Patients
Surgery
Thoracic Surgery
Vascular Surgery
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Summary:Background While anti-p53 antibody (p53-Ab) is a potential marker for early detection of colorectal cancer, its clinical utility in patients with advanced colorectal cancer remains unknown. Methods The clinical significance of p53-Ab was investigated by analyzing the data of 206 patients who underwent curative resection for colorectal liver metastases. Results Of the 206 patients, 60 (29%) were seropositive and 146 were seronegative for p53-Ab before the surgery. The preoperative serum p53-Ab level showed no significant correlation with the serum CEA or serum CA19-9 levels. The perioperative changes in serum p53-Ab positivity were significantly correlated with the preoperative serum p53-Ab levels and multivariate analysis confirmed that a higher preoperative p53-Ab level was independently associated with a worse recurrence-free survival (hazard ratio [HR], 1.07; 95% CI, 1.01–1.13; P  = 0.033 per + 100 U/mL), even after adjustments for other oncological factors, including the preoperative serum CEA level. Conclusion Higher preoperative p53-Ab levels were associated with a higher risk of recurrence after curative resection of colorectal liver metastases.
ISSN:0364-2313
1432-2323
DOI:10.1007/s00268-021-06049-9