Sex differences in transaortic flow rate and association with all-cause mortality in patients with severe aortic stenosis

Abstract Aims It is not known whether transaortic flow rate (FR) in aortic stenosis (AS) differs between men and women, and whether the commonly used cut-off of 200 mL/s is prognostic in females. We aimed to explore sex differences in the determinants of FR, and determine the best sex-specific cut-o...

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Bibliographic Details
Published in:European heart journal cardiovascular imaging 2021-09, Vol.22 (9), p.977-982
Main Authors: Saeed, Sahrai, Vamvakidou, Anastasia, Zidros, Spyridon, Papasozomenos, George, Lysne, Vegard, Khattar, Rajdeep S., Senior, Roxy
Format: Article
Language:English
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Summary:Abstract Aims It is not known whether transaortic flow rate (FR) in aortic stenosis (AS) differs between men and women, and whether the commonly used cut-off of 200 mL/s is prognostic in females. We aimed to explore sex differences in the determinants of FR, and determine the best sex-specific cut-offs for prediction of all-cause mortality. Methods and results Between 2010 and 2017, a total of 1564 symptomatic patients (mean age 76 ± 13 years, 51% men) with severe AS were prospectively included. Mean follow-up was 35 ± 22 months. The prevalence of cardiovascular disease was significantly higher in men than women (63% vs. 42%, P 
ISSN:2047-2404
2047-2412
DOI:10.1093/ehjci/jeab045