Bone substitutes and photobiomodulation in bone regeneration: A systematic review in animal experimental studies

In general, bone fractures are able of healing by itself. However, in critical situations such as large bone defects, poor blood supply or even infections, the biological capacity of repair can be impaired, resulting in a delay of the consolidation process or even in non‐union fractures. Thus, techn...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2021-09, Vol.109 (9), p.1765-1775
Main Authors: Magri, Angela Maria Paiva, Parisi, Júlia Risso, Andrade, Ana Laura Martins, Rennó, Ana Claudia Muniz
Format: Article
Language:English
Subjects:
Animal models
Animal research
Animals
Biocompatible Materials - pharmacology
Biomaterials
Biomedical materials
Bone biomaterials
Bone growth
Bone healing
bone regeneration
Bone Regeneration - drug effects
Bone Regeneration - physiology
Bone Regeneration - radiation effects
bone substitutes
Bone Substitutes - pharmacology
bone tissue
ceramic biomaterial
Ceramics
Defects
Fractures
Healing
Hydroxyapatite
Light therapy
Low-Level Light Therapy
photobiomodulation
Regeneration
Regeneration (physiology)
Repair
Reviews
Silicic acid
Substitute bone
Systematic review
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Summary:In general, bone fractures are able of healing by itself. However, in critical situations such as large bone defects, poor blood supply or even infections, the biological capacity of repair can be impaired, resulting in a delay of the consolidation process or even in non‐union fractures. Thus, technologies able of improving the process of bone regeneration are of high demand. In this context, ceramic biomaterials‐based bone substitutes and photobiomodulation (PBM) have been emerging as promising alternatives. Thus, the present study performed a systematic review targeting to analyze studies in the literature which investigated the effects of the association of ceramic based bone substitutes and PBM in the process of bone healing using animal models of bone defects. The search was conducted from March and April of 2019 in PubMed, Web of Science and Scopus databases. After the eligibility analyses, 16 studies were included in this review. The results showed that the most common material used was hydroxyapatite (HA) followed by Biosilicate associated with infrared PBM. Furthermore, 75% of the studies demonstrated positive effects to stimulate bone regeneration from association of ceramic biomaterials and PBM. All studies used low‐level laser therapy (LLLT) device and the most studies used LLLT infrared. The evidence synthesis was moderate for all experimental studies for the variable histological analysis demonstrating the efficacy of techniques on the process of bone repair stimulation. In conclusion, this review demonstrates that the association of ceramic biomaterials and PBM presented positive effects for bone repair in experimental models of bone defects.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.37170