Biomedical Applications of Electrospun Graphene Oxide

• Published in: ACS biomaterials science & engineering 2021-04, Vol.7 (4), p.1278-1301
• Main Authors: Grant, Jamie J, Pillai, Suresh C, Hehir, Sarah, McAfee, Marion, Breen, Ailish
• Format: Article
• Language: English
• Subjects: Biocompatible Materials; Graphite; Tissue Engineering; Wound Healing
• ISSN: 2373-9878; 2373-9878
• DOI: 10.1021/acsbiomaterials.0c01663

Graphene oxide (GO) has broad potential in the biomedical sector. The oxygen-abundant nature of GO means the material is hydrophilic and readily dispersible in water. GO has also been known to improve cell proliferation, drug loading, and antimicrobial properties of composites. Electrospun composites likewise have great potential for biomedical applications because they are generally biocompatible and bioresorbable, possess low immune rejection risk, and can mimic the structure of the extracellular matrix. In the current review, GO-containing electrospun composites for tissue engineering applications are described in detail. In addition, electrospun GO-containing materials for their use in drug and gene delivery, wound healing, and biomaterials/medical devices have been examined. Good biocompatibility and anionic-exchange properties of GO make it an ideal candidate for drug and gene delivery systems. Drug/gene delivery applications for electrospun GO composites are described with a number of examples. Various systems using electrospun GO-containing therapeutics have been compared for their potential uses in cancer therapy. Micro- to nanosized electrospun fibers for wound healing applications and antimicrobial applications are explained in detail. Applications of various GO-containing electrospun composite materials for medical device applications are listed. It is concluded that the electrospun GO materials will find a broad range of biomedical applications such as cardiac patches, medical device coatings, sensors, and triboelectric nanogenerators for motion sensing and biosensing.