Survival and complications after neoadjuvant chemotherapy or chemoradiotherapy for esophageal cancer: a meta-analysis

To identify the effective approach between neoadjuvant chemotherapy (NCT) and chemoradiotherapy (NCRT) by comparing patient survival and complications. A systematic literature search of articles published between January 1980 and October 2020 was conducted. Data were extracted and analyzed with STAT...

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Bibliographic Details
Published in:Future oncology (London, England) England), 2021-06, Vol.17 (17), p.2257-2274
Main Authors: Han, Jinmin, Wang, Zhongtang, Liu, Chengxin
Format: Article
Language:English
Subjects:
complications
esophageal cancer
meta-analysis
neoadjuvant treatment
survival
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Summary:To identify the effective approach between neoadjuvant chemotherapy (NCT) and chemoradiotherapy (NCRT) by comparing patient survival and complications. A systematic literature search of articles published between January 1980 and October 2020 was conducted. Data were extracted and analyzed with STATA 12.0. Five randomized trials and 15 retrospective studies, including 4529 patients (NCT: 2035; NCRT: 2494), were enrolled. Compared with NCT, NCRT provided a higher 3-year survival benefit, higher R0 resection and pathological complete response rates and lower local recurrence and distant metastasis rates, but no increase in 5-year survival. Perioperative mortality and cardiovascular complications were more common in patients with adenocarcinoma. Further studies should concentrate on identifying the optimal neoadjuvant approach and suitable beneficiaries.
ISSN:1479-6694
1744-8301
DOI:10.2217/fon-2021-0021