The role of LTBPs in TGF beta signaling

The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences...

Full description

Saved in:
Bibliographic Details
Published in:Developmental dynamics 2022-01, Vol.251 (1), p.95-104
Main Authors: Rifkin, Daniel, Sachan, Nalani, Singh, Karan, Sauber, Elyse, Tellides, George, Ramirez, Francesco
Format: Article
Language:English
Subjects:
Animals
cell signaling
Growth factors
Humans
Latent TGF-beta Binding Proteins - genetics
Latent TGF-beta Binding Proteins - metabolism
LTBP
Mice
mouse mutants
Protein Binding
Signal Transduction
TGF beta
Transforming Growth Factor beta - metabolism
Transforming growth factor-b
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this review is to discuss the transforming growth factor beta (TGFB) binding proteins (LTBP) with respect to their participation in the activity of TGFB. We first describe pertinent aspects of the biology and cell function of the LTBPs. We then summarize the physiological consequences of LTBP loss in humans and mice. Finally, we consider a number of outstanding questions relating to LTBP function. Key Findings LTBPs may mediate latent TGFB activation. LTBPs may yield tissue and temporal specificity to latent TGFB activation. LTBPs may control latent TGFB distribution.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.331