Comparison of the effectiveness of Ankaferd Blood Stopper® and Emdogain in periodontal regeneration

Objectives The present study was performed to compare the effectiveness of Ankaferd Blood Stopper® (ABS) with enamel matrix derivatives (EMD) for treating fenestration defects in rats. Materials and Methods Forty‐eight male Wistar rats were randomly divided into six groups (each n = 8). Fenestration...

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Bibliographic Details
Published in:Oral diseases 2022-10, Vol.28 (7), p.1947-1957
Main Authors: Güler, Şevki, Cetinkaya, Burcu Ozkan, Kurt Bayrakdar, Sevda, Ayas, Bülent, Keles, Gonca Cayir
Format: Article
Language:English
Subjects:
Ankaferd Blood Stopper
Collagen
Dental enamel
Emdogain
histomorphometric
Immunoreactivity
Osteopontin
Performance evaluation
Regeneration
Rodents
type‐III collagen
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Summary:Objectives The present study was performed to compare the effectiveness of Ankaferd Blood Stopper® (ABS) with enamel matrix derivatives (EMD) for treating fenestration defects in rats. Materials and Methods Forty‐eight male Wistar rats were randomly divided into six groups (each n = 8). Fenestration defects were created in all rats, to which ABS, EMD, or saline (S) was then applied. The rats were grouped and sacrificed at one of two different time points, as follows: ABS‐10‐group, ABS‐treatment/sacrifice on day 10; EMD‐10‐group, EMD‐treatment/sacrifice on day 10; S‐10‐group, S‐treatment/sacrifice on day 10; ABS‐38‐group, ABS‐treatment/sacrifice on day 38; EMD‐38‐group, EMD‐treatment/sacrifice on day 38; and S‐38‐group, S‐treatment/sacrifice on day 38. Then, histomorphometric analysis including measurements of new bone area (NBA) and new bone ratio (NBR), and immunohistochemical analysis including the determination of osteopontin (OPN) and type‐III‐collagen (C‐III) expression were performed. Results The NBA and NBR were significantly higher in the ABS‐10‐group and EMD‐10‐group compared to the S‐10‐group (p 
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.13852