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Effect and mechanism of berberine against polycystic ovary syndrome

For women of reproductive age, polycystic ovary syndrome (PCOS) is not a rare heterogeneous endocrine disorder and metabolic dysfunction. Menstrual problems, hyperandrogenism, polycystic ovary (PCO) and infertility often affect these women, and they are also prone to metabolic syndrome (MS) and insu...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2021-06, Vol.138, p.111468-111468, Article 111468
Main Authors: Zhang, Si-wei, Zhou, Jing, Gober, Hans-Jürgen, Leung, Wing Ting, Wang, Ling
Format: Article
Language:English
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Summary:For women of reproductive age, polycystic ovary syndrome (PCOS) is not a rare heterogeneous endocrine disorder and metabolic dysfunction. Menstrual problems, hyperandrogenism, polycystic ovary (PCO) and infertility often affect these women, and they are also prone to metabolic syndrome (MS) and insulin resistance (IR). As an isoquinoline alkaloid, Berberine (BBR) is the main effective component of Coptis. BBR, as a multi-target, multi-path plant extract, can interfere with the development of PCOS and relate to pathological process from many aspects, with less adverse reactions. It is mentioned in this review that BBR can alleviate IR, reduce the level of serum androgen, regulate lipid metabolism and moderate chronic inflammation. BBR is often used in combination with metformin, compound cyproterone (CPA) and other drugs, in order to achieve better therapeutic effect on PCOS. [Display omitted] •Alleviate IR is the core mechanism of BBR in the treatment of PCOS.•PPAR, MAPK and AMPK are the key pathways for BBR to act on patients with PCOS.•BBR combined with metformin, PCA and other drugs can improve the curative effect.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2021.111468