Role of pyroptosis in cancer cells and clinical applications

Chemotherapy drugs usually inhibit tumor cell growth through the apoptosis pathway. However, tumor cells become resistant to chemotherapy drugs by evading apoptosis. It is necessary to find new ways to inhibit tumor growth through other types of death. Pyroptosis is a recently identified inflammator...

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Bibliographic Details
Published in:Biochimie 2021-06, Vol.185, p.78-86
Main Authors: Ju, Xiaoli, Yang, Zhilong, Zhang, Heng, Wang, Qiang
Format: Article
Language:English
Subjects:
Gasdermins
inflammasomes
Pyroptosis
Tumor immunity
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Summary:Chemotherapy drugs usually inhibit tumor cell growth through the apoptosis pathway. However, tumor cells become resistant to chemotherapy drugs by evading apoptosis. It is necessary to find new ways to inhibit tumor growth through other types of death. Pyroptosis is a recently identified inflammatory cell death that plays an important role in a variety of diseases, including cancer. In this review, we will systematically review recent progress in the pyroptosis signaling pathway, the role of inflammasomes in cancer in the context of pyroptosis, the role of gasdermin proteins in cancer and the role of pyroptosis in tumor immunity. We will also discuss the application of the pyroptosis pathway in clinical studies. Finally, we hope to provide new strategies for pyroptosis in the clinic. [Display omitted] •Pyroptosis involve in cancer pathway.•The pyroptosis signaling pathway is complex.•Many clinical drugs induce pyroptosis in cancer cells.
ISSN:0300-9084
1638-6183
DOI:10.1016/j.biochi.2021.03.007