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The Modic‐endplate‐complex phenotype in cervical spine patients: Association with symptoms and outcomes

This study describes a novel, combined Modic changes (MC) and structural endplate abnormality phenotype of the cervical spine, which we have termed the Modic‐Endplate‐Complex (MEC), and its association with preoperative symptoms and outcomes in anterior cervical discectomy and fusion (ACDF) patients...

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Published in:Journal of orthopaedic research 2022-02, Vol.40 (2), p.449-459
Main Authors: Baker, James D., Sayari, Arash J., Harada, Garrett K., Tao, Youping, Louie, Philip K., Basques, Bryce A., Galbusera, Fabio, Niemeyer, Frank, Wilke, Hans‐Joachim, An, Howard S., Samartzis, Dino
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Language:English
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Summary:This study describes a novel, combined Modic changes (MC) and structural endplate abnormality phenotype of the cervical spine, which we have termed the Modic‐Endplate‐Complex (MEC), and its association with preoperative symptoms and outcomes in anterior cervical discectomy and fusion (ACDF) patients. This was a retrospective study of prospectively collected data at a single institution. Preoperative cervical magnetic resonance imagings were used to assess the presence of MC and endplate abnormalities. Patients were divided into four groups: MC‐only, endplate abnormality‐only, the MEC and controls. The MEC was defined as the presence of both a MC and endplate abnormality in the cervical spine. Phenotypes were further stratified by location and compared to controls. Associations with patient‐reported outcome measures were assessed using regression controlling for baseline characteristics. A total of 628 patients were included, with 84 MC‐only, 166 endplate abnormality‐only, and 187 MEC patients. Both MC (p 
ISSN:0736-0266
1554-527X
DOI:10.1002/jor.25042