Dispersion of mean consecutive differences in single‐fiber electromyography increases diagnostic sensitivity for myasthenia gravis

Introduction In this study we aimed to investigate the dispersion of mean consecutive difference (MCD) of concentric needle jitter studies of patients with myasthenia gravis (MG) and its effect on diagnostic sensitivity for MG. Methods One hundred fifty‐three patients, including 76 patients with MG...

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Bibliographic Details
Published in:Muscle & nerve 2021-06, Vol.63 (6), p.885-889
Main Authors: Kojima, Yuta, Shibuya, Kazumoto, Uzawa, Akiyuki, Kano, Hiroki, Nakamura, Keigo, Yasuda, Manato, Suzuki, Yo‐ichi, Tsuneyama, Atsuko, Suichi, Tomoki, Ozawa, Yukiko, Misawa, Sonoko, Noto, Yu‐ichi, Mizuno, Toshiki, Kuwabara, Satoshi
Format: Article
Language:English
Subjects:
Coefficient of variation
concentric needle electrode
Criteria
Diagnosis
diagnostic criteria
Diagnostic systems
Dispersion
Electromyography
Mathematical analysis
Mean
mean consecutive difference
Medical diagnosis
Muscles
Myasthenia
Myasthenia gravis
Neuromuscular junctions
Outliers (statistics)
Signs and symptoms
Vibration
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Summary:Introduction In this study we aimed to investigate the dispersion of mean consecutive difference (MCD) of concentric needle jitter studies of patients with myasthenia gravis (MG) and its effect on diagnostic sensitivity for MG. Methods One hundred fifty‐three patients, including 76 patients with MG and 77 controls with possible MG who later received another diagnosis, underwent stimulated concentric needle jitter studies of the frontalis muscle. MCD mean, standard deviation (SD), and coefficient of variation (CV) were calculated. Diagnostic sensitivity and specificity were determined using receiver operating characteristic (ROC) analyses. Results MG patients showed a significantly greater MCD mean (MG: control, 26.3 μs; 13.5 μs [median]; P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.27236