Thermodynamic inconsistency disproves the Suga-Sagawa theory of cardiac energetics

The theory proposed by Suga and Sagawa, encompassing the concepts of ‘time-varying elastance’, ‘pressure-volume area’ and ‘isoefficiency’, has been widely applied in cardiac research - albeit not without contention. In this Review, we commence with a brief history of striated muscle energetics as a...

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Bibliographic Details
Published in:Progress in biophysics and molecular biology 2021-09, Vol.164, p.81-91
Main Authors: Loiselle, Denis S., Taberner, Andrew J., Tran, Kenneth, Han, June-Chiew
Format: Article
Language:English
Subjects:
Cardiac thermodynamics
Enthalpy
Mechanical efficiency of the myocardium
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Summary:The theory proposed by Suga and Sagawa, encompassing the concepts of ‘time-varying elastance’, ‘pressure-volume area’ and ‘isoefficiency’, has been widely applied in cardiac research - albeit not without contention. In this Review, we commence with a brief history of striated muscle energetics as a prelude to re-visiting the Suga-Sagawa Theory. We conclude our discussion by including recent insights into the fundamental flaw underlying the metabolic component of the Theory.
ISSN:0079-6107
1873-1732
DOI:10.1016/j.pbiomolbio.2021.03.002