Role of pyroptosis in atherosclerosis and its therapeutic implications

Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflamma...

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Bibliographic Details
Published in:Journal of cellular physiology 2021-10, Vol.236 (10), p.7159-7175
Main Authors: He, Bin, Nie, Qiangqiang, Wang, Feng, Han, Yongxin, Yang, Bo, Sun, Mingsheng, Fan, Xueqiang, Ye, Zhidong, Liu, Peng, Wen, Jianyan
Format: Article
Language:English
Subjects:
anti‐inflammatory treatment
Arteriosclerosis
Atherosclerosis
caspase‐1
Cell death
Cell size
Chemical compounds
Cytokines
GSDMD
inflammation
Inflammatory diseases
Interleukins
NLRP3
Pharmacology
Pyroptosis
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Summary:Atherosclerosis is a significant cardiovascular burden and a leading cause of death worldwide, recognized as a chronic sterile inflammatory disease. Pyroptosis is a novel proinflammatory regulated cell death, characterized by cell swelling, plasma membrane bubbling, and robust release of proinflammatory cytokines (such as interleukin IL‐1β and IL‐18). Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis. Graphical Mounting studies have addressed the crucial contribution of pyroptosis to atherosclerosis and clarified the candidate therapeutic agents targeting pyroptosis for atherosclerosis. Herein, we review the initial characterization of pyroptosis, the detailed mechanisms of pyroptosis, current evidence about pyroptosis and atherosclerosis, and potential therapeutic strategies that target pyroptosis in the development of atherosclerosis.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.30366