Effects of dutasteride on sex hormones and cerebrospinal steroids in patients treated for benign prostatic hyperplasia

Purpose Neuroactive steroids may have a role in regulating sexual function. This case-control study assessed whether dutasteride, a 5α-reductase inhibitor used for treatment of patients with benign prostate hyperplasia (BPH), impacts on the levels of neuroactive steroids, leading to erectile dysfunc...

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Bibliographic Details
Published in:Endocrine 2021-09, Vol.73 (3), p.712-718
Main Authors: Favilla, Vincenzo, Cannarella, Rossella, Trovato, Federica, Li Volti, Giovanni, Distefano, Alfio, Grimaldi, Enrico, La Camera, Giuseppa, La Vignera, Sandro, Condorelli, Rosita A., Calogero, Aldo E., Cimino, Sebastiano
Format: Article
Language:English
Subjects:
17β-Estradiol
Anesthesia
Case-Control Studies
Cerebrospinal fluid
Diabetes
Dihydrotestosterone
Dutasteride - therapeutic use
Endocrinology
Erectile dysfunction
Gonadotropins
Humanities and Social Sciences
Humans
Hyperplasia
Internal Medicine
Male
Medicine
Medicine & Public Health
multidisciplinary
Neurosteroids
Original Article
Patients
Pituitary (anterior)
Prostate
Prostatectomy
Prostatic Hyperplasia - drug therapy
Science
Serum levels
Sex hormones
Steroids
Surgery
Testosterone
Urinary tract
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Summary:Purpose Neuroactive steroids may have a role in regulating sexual function. This case-control study assessed whether dutasteride, a 5α-reductase inhibitor used for treatment of patients with benign prostate hyperplasia (BPH), impacts on the levels of neuroactive steroids, leading to erectile dysfunction (ED) and/or hypoactive sexual desire (HSD). Methods Forty patients with BPH and moderate-to-severe lower urinary tract symptoms (LUTS), pre-scheduled for prostate transurethral resection or open prostatectomy were enrolled. Twenty of these patients with prostate volume ≤40 mL were treated with α-blockers (Group A) and the remaining 20, with prostate volume >40 mL, with dutasteride plus α-blockers (Group B) for at least 6 months before surgery. Serum sex steroids and gonadotropin levels were measured the day before surgery, and the neuroactive steroid levels were assessed in the cerebrospinal fluid (CSF) collected during spinal anesthesia, at the day of surgery. Results Before surgery, the International Index of Erectile Function 5-item score was higher in Group A that Group B (18.8 ± 4.8 vs. 15.1 ± 5.4, p  
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-021-02675-4