Preoperative nomogram to predict posthepatectomy liver failure

Background and Objectives Posthepatectomy liver failure (PHLF) is associated with significant morbidity and mortality. However, it is often difficult to predict the risk of PHLF in an individual patient. We aimed to develop a preoperative nomogram to predict PHLF and allow better risk stratification...

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Bibliographic Details
Published in:Journal of surgical oncology 2021-05, Vol.123 (8), p.1750-1756
Main Authors: Dhir, Mashaal, Samson, Kaeli K., Yepuri, Natesh, Yanala, Ujwal R., Smith, Lynette M., Are, Chandrakanth
Format: Article
Language:English
Subjects:
Cancer surgery
hepatectomy
Liver
liver failure
liver resection
nomogram
Nomograms
Patients
Perioperative care
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Summary:Background and Objectives Posthepatectomy liver failure (PHLF) is associated with significant morbidity and mortality. However, it is often difficult to predict the risk of PHLF in an individual patient. We aimed to develop a preoperative nomogram to predict PHLF and allow better risk stratification before surgery. Methods Data for patients undergoing a partial or major hepatectomy were extracted from the hepatectomy‐specific NSQIP database for years 2014–2016. Data set from 2017 was used for validation. Patients with Grade B/C liver failure were compared with patients with no liver failure. Results A total of 10 808 patients from 2014–2016 data set were included. Of these, 316 patients (2.9%) developed Grade B/C PHLF. In the multivariable model consisting of preoperative variables, the following were predictive of Grade B/C PHLF (all p 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.26463