Prevalence and risk factors of overweight and obesity in Chinese patients with first-episode drug-naïve major depressive disorder

•To the best of our knowledge, it is the first study to explore the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.•Exploring the possible link between BMI and TSH, HAMD as well as inflammatory factors in FEDN patients with MD...

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Bibliographic Details
Published in:Journal of affective disorders 2021-05, Vol.286, p.351-359
Main Authors: Si, Tong, Yang, Kun, Lang, XiaoE, Dong, Xinglu, Wang, Ningqun, Zhang, Xiangyang, Qu, Miao
Format: Article
Language:English
Subjects:
China - epidemiology
Cross-Sectional Studies
Depressive Disorder, Major - epidemiology
Humans
Major depressive disorder
Obesity
Obesity - epidemiology
Overweight
Overweight - epidemiology
Pharmaceutical Preparations
Prevalence
Risk Factors
Thyroid stimulating hormone
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Summary:•To the best of our knowledge, it is the first study to explore the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China.•Exploring the possible link between BMI and TSH, HAMD as well as inflammatory factors in FEDN patients with MDD.•Providing related clinical implications and possible mechanisms from the perspective of neuroendocrine and neuroimmune. Obesity and overweight are common in patients with major depressive disorder (MDD); the results are inconsistent due to confounding variables involved in studies. Furthermore, no well-designed study has been published to investigate the prevalence, risk factors and underlying mechanisms of obesity/overweight in Chinese MDD patients. This study aimed to investigate the prevalence of obesity/overweight and related risk factors in first-episode, drug-naïve (FEDN) patients with MDD in China. A total of 1718 patients were recruited. Their clinical and anthropometric data, thyroid function and biochemical parameters were collected. All patients were evaluated on the 17-item Hamilton Rating Scale for Depression, 14-item Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale. The prevalence of obesity and overweight was 3.73% and 56.00%, respectively. Multivariable logistic regression analysis showed that TSH was the only independent risk factor for weight gain in MDD patents. The fitting curve of the relationship between TSH and BMI formed an inverted U-shaped parabola. The ordinal logit mode showed that when TSH
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2021.01.037