A snapshot of human leukocyte antigen (HLA) diversity using data from the Allele Frequency Net Database

The extensive allelic variability observed in several genes related to the immune response and its significance in different areas including transplantation, disease association studies, diversity in human populations, among many others, has led the scientific community to analyse these variants amo...

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Bibliographic Details
Published in:Human immunology 2021-07, Vol.82 (7), p.496-504
Main Authors: Gonzalez-Galarza, Faviel F., McCabe, Antony, Melo dos Santos, Eduardo J., Jones, Andrew R, Middleton, Derek
Format: Article
Language:English
Subjects:
Alleles
Databases, Genetic
Gene Frequency
Genetic diversity
Genetic Variation
HLA
HLA Antigens - genetics
HLA Antigens - immunology
Humans
Immunogenetics - methods
Immunogenetics databases
Transplantation Immunology
Web Browser
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Summary:The extensive allelic variability observed in several genes related to the immune response and its significance in different areas including transplantation, disease association studies, diversity in human populations, among many others, has led the scientific community to analyse these variants among individuals. Serving as an electronic data warehouse, the Allele Frequency Net Database (AFND, http://www.allelefrequencies.net) contains data on the frequency of immune related genes and their corresponding alleles from more than 1700 worldwide population samples covering more than ten million unrelated individuals. The collection of population data sets available in AFND encompasses different polymorphic regions including the highly-polymorphic human leukocyte antigen (HLA) system for which more than 1200 populations are available. In this article, we provide an insight of the high diversity found in the HLA region by examining population data sets stored in AFND, as well as a description of the available data sets for further analyses.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2020.10.004