The absolute tumor-capsule contact length in the diagnosis of extraprostatic extension of prostate cancer

Background Extraprostatic extension (EPE) of prostate cancer is associated with a poor prognosis. The broad-based capsule-tumor interface has been recognized as one of the worrisome imaging features in multiparametric prostate MRI (mpMRI). However, there was significant heterogeneity among the measu...

Full description

Saved in:
Bibliographic Details
Published in:Abdominal imaging 2021-08, Vol.46 (8), p.4014-4024
Main Authors: Eurboonyanun, Kulyada, Pisuchpen, Nisanard, O’Shea, Aileen, Lahoud, Rita Maria, Atre, Isha D., Harisinghani, Mukesh
Format: Article
Language:English
Subjects:
Accuracy
Contact length
Diagnosis
Diagnostic systems
Gastroenterology
Hepatology
Heterogeneity
Humans
Imaging
Magnetic Resonance Imaging
Male
Measurement methods
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Multiparametric Magnetic Resonance Imaging
Optimization
Patients
Pelvis
Prostate cancer
Prostatectomy
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - surgery
Radiology
Retrospective Studies
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Extraprostatic extension (EPE) of prostate cancer is associated with a poor prognosis. The broad-based capsule-tumor interface has been recognized as one of the worrisome imaging features in multiparametric prostate MRI (mpMRI). However, there was significant heterogeneity among the measurement method used in prior studies. Objectives This study’s objectives were to investigate and compare the accuracy between the curvilinear and linear measurement, find the optimal cut-off contact surface threshold for the diagnosis of EPE, and assess the benefit of the additional contact surface measurement versus visual assessment alone. Methods The status of EPE in mpMRI and the overall PI-RADS were assessed. The tumor’s dimensions, the actual tumor-capsule contact length (ACTCL), and the absolute tumor-capsule contact length (ABTCL) were measured. The parameters were analyzed and correlated with the EPE status from prostatectomy specimens. Results Ninety-five patients who underwent mpMRI followed by prostatectomy were included in the study. High Gleason score (score 8–9), radiologist’s impression of EPE, and PI-RADS 5 were significantly correlated with EPE in surgical specimens ( p  = 0.014, p  
ISSN:2366-004X
2366-0058
DOI:10.1007/s00261-021-03063-2