Effects of Banafine®, a fermented green banana‐derived acidic glycoconjugate, on influenza vaccine antibody titer in elderly patients receiving gastrostomy tube feeding

Immunosenescence can negatively affect cytokine production in elderly and may impair poor antibody responses to influenza vaccination and infection. Herein, the effects of Banafine® administration on influenza vaccine antibody titer in elderly patients (average age ∼80 years) receiving gastrostomy t...

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Bibliographic Details
Published in:Journal of food science 2021-04, Vol.86 (4), p.1410-1417
Main Authors: Horie, Kenji, Hossain, Md. Saddam, Kim, Yugweng, Akiko, Ishida, Kon, Ryoko, Yamatsu, Atsushi, Kishima, Masako, Nishikimi, Toshio, Kim, Mujo
Format: Article
Language:English
Subjects:
Antibodies
Banafine
Cytokines
elderly patients
Enteral nutrition
Fermented food
Hemagglutination inhibition
Immobilization
Immune response
Immunosenescence
Influenza
influenza vaccine
Innate immunity
Literature reviews
Older people
Ostomy
Placebos
Probiotics
Seroconversion
Vaccination
Vaccines
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Summary:Immunosenescence can negatively affect cytokine production in elderly and may impair poor antibody responses to influenza vaccination and infection. Herein, the effects of Banafine® administration on influenza vaccine antibody titer in elderly patients (average age ∼80 years) receiving gastrostomy tube feeding were examined. In the double‐blind, single‐center, randomized clinical studies, 30 elderly bedridden patients were administered Banafine® or placebo for 8 weeks. At week 4, all patients received influenza vaccination against H1N1, H3N2, B/Yamagata, or B/Victoria. Blood biochemical indices and serum antibody titers were assessed. Banafine® administration significantly increased hemagglutination inhibition titers in response to vaccination against H1N1, H3N2, and B/Yamagata in the elderly patients (P 
ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.15675