The influence of dietary Motore™ supplement on antioxidant status to Aeromonas hydrophila infection in Rhamdia quelen

• Published in: Microbial pathogenesis 2021-05, Vol.154, p.104871-104871, Article 104871
• Main Authors: Franco, Fernando Wendel, Bandeira Junior, Guerino, Dolci, Geisa Sorezina, Barbosa, Luísa Barichello, Sartori Oliveira, Carla Elena, de Freitas Souza, Carine, Escobar Burger, Marilise, Baldisserotto, Bernardo, Heinzmann, Berta Maria
• Format: Article
• Language: English
• Subjects: Aeromonosis; Curcuma longa food additive; Oxidative stress; Silver catfish
• ISSN: 0882-4010; 1096-1208
• DOI: 10.1016/j.micpath.2021.104871

This study points to evaluate the effects of pre-treatment with standardized dry extract of Curcuma longa (Motore™) added to the diet (0; 250; 500; and 750 mg/kg) on oxidative stress parameters, longevity, and therapeutic success in Rhamdia quelen experimentally infected with Aeromonas hydrophila (MF 372510). After treatment, the liver and kidney were collected to determine non-enzymatic oxidative parameters such as the formation of thiobarbituric acid reactive substances (TBARS), non-protein thiols (NPSH), and quantification of reactive oxygen species (ROS) levels. Also, two enzymatic antioxidant parameters were evaluated: superoxide dismutase (SOD) and catalase (CAT) activities. The results showed an increase of ROS and TBARS levels, a depletion in NPSH, and a decrease of SOD and CAT activities in infected fish compared to control. The highest Motore™ dose minimized the deleterious effect of A. hydrophila infection improving longevity, oxidative status, and survival rate. The addition of 750 mg Motore™/kg feed is recommended for silver catfish in fish farming. Serious economic losses in Rhamdia quelen culture caused by Aeromonas hydrophila infections can be prevented by the addition of Motore™ to the diet. •(MotoreTM) 750 mg/kg feed (in Rhamdia quelen diet experimentally infected with A. hydrophila MF 372510).•Significantly prevents oxidative damage (Tbars, ROS, NPSH, Sod, Cat).•Minimizes Mortality (%), increases the longevity (days) of the animals.•Guarantees a significant therapeutic success (%).