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Prolonged chronic social defeat stress promotes less resilience and higher uniformity in depression-like behaviors in adult male mice

Chronic social defeat stress (CSDS) is widely applied to study of depression in rodents. 10-day CSDS was a most commonly employed paradigm but with high resilience ratio (∼30%), producing potential variation in depression-like behavioral symptoms. Whether prolonged period (21 days) of CSDS would pro...

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Published in:Biochemical and biophysical research communications 2021-05, Vol.553, p.107-113
Main Authors: Lu, Jian, Gong, Xue, Yao, Xiao, Guang, Yu, Yang, Hongjiang, Ji, Runan, He, Yong, Zhou, Wei, Wang, Haiyang, Wang, Wei, Bai, Shunjie, Guo, Hua, Guo, Zengcai V., Xie, Peng
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Language:English
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Summary:Chronic social defeat stress (CSDS) is widely applied to study of depression in rodents. 10-day CSDS was a most commonly employed paradigm but with high resilience ratio (∼30%), producing potential variation in depression-like behavioral symptoms. Whether prolonged period (21 days) of CSDS would promote less resilience and reduce behavioral variability remains unknown. We applied 10-day and 21-day CSDS paradigms to induce mouse model of depression and compared their resilience ratio and behavioral phenotypes. Mice under 21-day CSDS had significantly lower resilience ratio and greater changes in behavioral indicators relative to mice under 10-day CSDS. Behavioral indicators from 21-day CSDS paradigm had higher correlations and better prediction for susceptibility which indicating higher uniformity in behavioral phenotypes. Furthermore, a subset of behavioral indicators in 21-day CSDS had high prediction efficacy and should be first applied to screen susceptibility of CSDS. Thus, our study demonstrates that 21-day CSDS is a more robust paradigm inducing reliable depression-like behaviors relative to 10-day CSDS, and should be preferentially used in rodent studies of depression. •21-day CSDS induces reliable depression-like behaviors with lower resilience ratio.•Behavioral phenotypes under 21-day CSDS have higher uniformity.•Behavioral indicators of 21-day CSDS have better prediction for susceptibility.•A subset of these behavioral indicators is with high prediction accuracy.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2021.03.058