Tritium labelling of two potent dopamine D2 receptor agonists at high specific activity

An efficient method is described to radiolabel several dopamine D2 receptor agonists with tritium at high specific activity. •This paper describes the tritium radiolabelling of two potent dopamine D2 receptor agonists.•A common and efficient synthetic route is outlined for these compounds that is bo...

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Bibliographic Details
Published in:Applied radiation and isotopes 2021-06, Vol.172, p.109670-109670, Article 109670
Main Authors: Filer, Crist N., Andrews, Joseph R., Pounds, Scot, Ullas, Giliyar V.
Format: Article
Language:English
Subjects:
Dopamine
Dopamine receptor
Tritium
Tritium NMR
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Summary:An efficient method is described to radiolabel several dopamine D2 receptor agonists with tritium at high specific activity. •This paper describes the tritium radiolabelling of two potent dopamine D2 receptor agonists.•A common and efficient synthetic route is outlined for these compounds that is both robust and scalable.•The products are prepared at high radiopurity and specific activity.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2021.109670