Chloroquine and hydroxychloroquine in antitumor therapies based on autophagy-related mechanisms

Chloroquine (CQ) and hydroxychloroquine (HCQ) are the most common drugs used to relieve acute and chronic inflammatory diseases. In this article, we present a review about the use of CQ and HCQ in antitumor therapies based on autophagy mechanisms. These molecules break/discontinue autophagosome-lyso...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacological research 2021-06, Vol.168, p.105582-105582, Article 105582
Main Authors: Ferreira, Paulo Michel Pinheiro, Sousa, Rayran Walter Ramos de, Ferreira, José Roberto de Oliveira, Militão, Gardenia Carmen Gadelha, Bezerra, Daniel Pereira
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Autophagy - drug effects
Cell death
Chemoresistance
Chloroquine - pharmacology
Chloroquine - therapeutic use
Clinical option
Clinical Trials as Topic
Drug Resistance, Neoplasm
Humans
Hydroxychloroquine - pharmacology
Hydroxychloroquine - therapeutic use
Immunomodulating Agents - pharmacology
Immunomodulatory properties
Neoplasms - drug therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chloroquine (CQ) and hydroxychloroquine (HCQ) are the most common drugs used to relieve acute and chronic inflammatory diseases. In this article, we present a review about the use of CQ and HCQ in antitumor therapies based on autophagy mechanisms. These molecules break/discontinue autophagosome-lysosome fusions in initial phases and enhance antiproliferative action of chemotherapeutics. Their sensitizing effects of chemotherapy when used as an adjuvant option in clinical trials against cancer. However, human related-MDR genes are also under risk to develop chemo or radioresistance because cancer cells have ability to throw 4-aminoquinolines out from digestive vacuoles well. Additionally, they also have antitumor mechanism unrelated to autophagy, including cell death from apoptosis and necroptosis and immunomodulatory/anti-inflammatory properties. However, the link between some anticancer mechanisms, clinical efficacy and pharmacological safety has not yet been fully defined. [Display omitted]
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2021.105582