Abnormal motor surround inhibition associated with cortical and deep grey matter involvement in multiple sclerosis

• Published in: Clinical neurophysiology 2021-05, Vol.132 (5), p.1151-1156
• Main Authors: Belvisi, D., Giannì, C., Tartaglia, M., Petsas, N., Baione, V., Crisafulli, S.G., Pantano, P., Berardelli, A., Conte, A.
• Format: Article
• Language: English
• Subjects: Basal ganglia; Motor control; Multiple sclerosis; Primary motor cortex; Surround inhibition; Transcranial magnetic stimulation
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2021.01.029

•Motor surround inhibition is abnormal in patients with multiple sclerosis.•In multiple sclerosis, motor surround inhibition abnormalities are associated with cortical and deep grey matter involvement.•Motor surround inhibition represents a new therapeutic target of rehabilitative approaches in multiple sclerosis. Motor surround inhibition (mSI) is a physiological mechanism that contributes to hand movement control by focusing voluntary movement. Growing evidence suggests that hand movement control is impaired in multiple sclerosis. The aim of the study was to evaluate mSI in MS and to investigate the brain structures involved in mSI in multiple sclerosis. We recruited 33 patients and 23 controls. To investigate mSI, we delivered transcranial magnetic single pulses during index finger flexion. Motor evoked potentials were recorded and first dorsal interosseous (“active muscle”) and from the abductor digiti minimi (“surround muscle”). mSI was expressed as the ratio between Motor evoked potentials recorded from the surround muscle during movement and at rest. Participants underwent a magnetic resonance study. Patients had impaired mSI as compared with controls. Magnetic resonance showed that basal ganglia had smaller volumes and higher mean diffusivity than controls. Impaired mSI correlated with primary motor cortex and basal ganglia involvement in multiple sclerosis. Altered mSI in multiple sclerosis is related to cortical and subcortical grey matter involvement. Our study provides the first demonstration of a pathophysiological mechanism underlying hand movement control dysfunction in multiple sclerosis. mSI represents a new therapeutic target of multiple sclerosis rehabilitative approaches.