Identification and Characterization of Epivascular Glia Using En Face Optical Coherence Tomography

The purpose of this study was to describe the clinical features of epivascular glia (EVG) using en face optical coherence tomography (OCT). Retrospective cross-sectional study. Single-institution en face OCT images were reviewed. Eyes displaying EVG were captured with manual internal limiting membra...

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Bibliographic Details
Published in:American journal of ophthalmology 2021-09, Vol.229, p.108-119
Main Authors: Grondin, Christelle, Au, Adrian, Wang, Derrick, Gunnemann, Frederic, Tran, Khoi, Hilely, Assaf, Sadda, SriniVas, Sarraf, David
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cross-Sectional Studies
Diabetic retinopathy
Epiretinal Membrane - diagnosis
Humans
Microscopy
Middle Aged
Neuroglia
Optics
Pathogenesis
Retina
Retrospective Studies
Tomography, Optical Coherence
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Summary:The purpose of this study was to describe the clinical features of epivascular glia (EVG) using en face optical coherence tomography (OCT). Retrospective cross-sectional study. Single-institution en face OCT images were reviewed. Eyes displaying EVG were captured with manual internal limiting membrane (ILM) segmentation and analyzed with customized segmentation . A random age- and sex-matched control group was selected to determine relative epiretinal membrane (ERM) prevalence. Characteristic hyper-reflective ILM plaques with dendrite-like radiations were identified using en face OCT and displayed vascular predilection. A total of 161 eyes with EVG (the EVG group) and 2,315 eyes without EVG (control group) were identified from a total cohort of 1,298 patients (or 2,476 eyes). The prevalence of EVG was 161 of 2,476 eyes (6.5%) and 119 of 1,298 patients (9.2%) in the cohort. Mean age was 79.3 ± 10.7 years old in the EVG group and 55.9 ± 24.6 years old in the control group (P
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2021.03.014