Chronic Invasive Fungal Sinusitis With Negative Histopathology: A Diagnostic Challenge

Although the diagnosis of chronic invasive fungal sinusitis relies chiefly on identification of invasive fungi on histology, the insidious nature of the disease can preclude detection of fungal organisms. Here, we present a case of chronic invasive fungal sinusitis with negative histopathologic find...

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Bibliographic Details
Published in:Ear, nose, & throat journal nose, & throat journal, 2023-05, Vol.102 (5), p.319-322
Main Authors: Ning, Anne, Kocharyan, Arminé, Brown, W Colby, D’Anza, Brian
Format: Article
Language:English
Subjects:
Case reports
Fungal infections
Humans
Invasive Fungal Infections
Medical diagnosis
Sinusitis
Sinusitis - microbiology
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Summary:Although the diagnosis of chronic invasive fungal sinusitis relies chiefly on identification of invasive fungi on histology, the insidious nature of the disease can preclude detection of fungal organisms. Here, we present a case of chronic invasive fungal sinusitis with negative histopathologic findings and a definitive diagnosis made through fungal DNA detection. Clinicians should consider polymerase chain reaction an important complement to histology and culture in the diagnosis of chronic invasive fungal sinusitis.
ISSN:0145-5613
1942-7522
DOI:10.1177/0145561320973773