Attenuated effect of the apolipoprotein E ɛ4 allele on neuropsychiatric symptoms among African older adults

Yoro-Zohoun et al. (2021) investigated the association between the apolipoprotein E (APOE) ɛ4 allele and neuropsychiatric symptoms (NPS) in 322 older adults from Central Africa. The sample had a high prevalence of the APOE ɛ4 allele, with 40% of older adults having at least one ɛ4 allele. Interestin...

Full description

Saved in:
Bibliographic Details
Published in:International psychogeriatrics 2021-03, Vol.33 (3), p.213-215
Main Authors: Suemoto, Claudia K., Ferri, Cleusa P.
Format: Article
Language:English
Subjects:
African Americans
Alleles
Alzheimer's disease
Anxiety
Apathy
Apolipoproteins
Caregivers
Carriers
Commentary
Dementia
Education
Hispanic people
Mental depression
Neuropsychiatric symptoms
Older people
Risk factors
Sociodemographics
Trends
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Yoro-Zohoun et al. (2021) investigated the association between the apolipoprotein E (APOE) ɛ4 allele and neuropsychiatric symptoms (NPS) in 322 older adults from Central Africa. The sample had a high prevalence of the APOE ɛ4 allele, with 40% of older adults having at least one ɛ4 allele. Interestingly, participants who were homozygous APOE ɛ4 allele carriers had less NPS in the previous 30 days compared to non-carriers in an analysis adjusted for sociodemographic variables and cognitive status. Non-significant trends were also found in participants who were heterozygous for the APOE ɛ4 allele, suggesting lower odds of NPS among these participants compared to non-APOE ɛ4 allele carriers.
ISSN:1041-6102
1741-203X
DOI:10.1017/S1041610221000107