Reinforcing adherence to lipid-lowering therapy after an acute coronary syndrome: A pragmatic randomized controlled trial

Achieving the low-density lipoprotein cholesterol (LDL-C) goal following an acute coronary syndrome (ACS) is a milestone often missed due to suboptimal adherence to secondary prevention treatments. Whether improved adherence could result in reduced LDL-C levels is unclear. We aimed to evaluate wheth...

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Bibliographic Details
Published in:Atherosclerosis 2021-04, Vol.323, p.37-43
Main Authors: Zafeiropoulos, Stefanos, Farmakis, Ioannis, Kartas, Anastasios, Arvanitaki, Alexandra, Pagiantza, Areti, Boulmpou, Aristi, Tampaki, Athina, Kosmidis, Diamantis, Nevras, Vassileios, Markidis, Eleftherios, Papadimitriou, Ioannis, Vlachou, Anastasia, Arvanitakis, Konstantinos, Miyara, Santiago J., Ziakas, Antonios, Molmenti, Ernesto P., Kassimis, George, Zanos, Stavros, Karvounis, Haralambos, Giannakoulas, George
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - drug therapy
Acute coronary syndromes
Cholesterol, LDL
Dyslipidemia
Dyslipidemias
Female
Humans
LDL-C goal
Male
Medication adherence
Middle Aged
Secondary Prevention
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Summary:Achieving the low-density lipoprotein cholesterol (LDL-C) goal following an acute coronary syndrome (ACS) is a milestone often missed due to suboptimal adherence to secondary prevention treatments. Whether improved adherence could result in reduced LDL-C levels is unclear. We aimed to evaluate whether an educational-motivational intervention increases long-term lipid-lowering therapy (LLT) adherence and LDL-C goal attainment rate among post-ACS patients. IDEAL-LDL was a parallel, two-arm, single-center, pragmatic, investigator-initiated randomized controlled trial. Hospitalized patients for ACS were randomized to a physician-led integrated intervention consisting of an educational session at baseline, followed by regular motivational interviewing phone sessions or usual care. Co-primary outcomes were the LLT adherence (measured by Proportion of Days Covered (PDC); good adherence defined as PDC>80%), and LDL-C goal (
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2021.03.013