Helicobacter pylori genotypes associated with gastric cancer and dysplasia in Colombian patients

Colombia has high incidence levels of gastric cancer that can be explained by the genetic variability of Helicobacter pylori (H. pylori). Our aim was to establish the relation of the H. pylori CagA and VacA genotypes to dysplasia and gastric cancer, in a high-risk population. A case-control study wa...

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Bibliographic Details
Published in:Revista de Gastroenterología de México (English Edition) 2022-04
Main Authors: Carlosama-Rosero, Y H, Acosta-Astaiza, C P, Sierra-Torres, C H, Bolaños-Bravo, H J
Format: Article
Language:eng ; spa
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Summary:Colombia has high incidence levels of gastric cancer that can be explained by the genetic variability of Helicobacter pylori (H. pylori). Our aim was to establish the relation of the H. pylori CagA and VacA genotypes to dysplasia and gastric cancer, in a high-risk population. A case-control study was conducted on 202 patients from a high-risk cancer zone. Patients with dysplasia and gastric cancer (cases) and patients with nonatrophic gastritis (controls) were included. Endoscopic sampling and histologic classification were carried out according to the Sydney system and the Lauren classification. Genetic information was obtained through polymerase chain reaction on paraffin blocks. The measures of association of the variables of interest were evaluated in bivariate and multivariate models. A P
ISSN:2255-534X
DOI:10.1016/j.rgmx.2021.01.005