PGC1A driven enhanced mitochondrial DNA copy number predicts outcome in pediatric acute myeloid leukemia

[Display omitted] •Mitochondrial DNA (mtDNA) copy number is elevated in pediatric AML patients.•Elevated mtDNA copy number predicts aggressive disease and lower survival outcomes.•MtDNA copy number is possibly driven by PGC1A, likely independent of MYC. Mitochondrial DNA (mtDNA) copy number alterati...

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Bibliographic Details
Published in:Mitochondrion 2021-05, Vol.58, p.246-254
Main Authors: Chaudhary, Shilpi, Ganguly, Shuvadeep, Palanichamy, Jayanth Kumar, Singh, Archna, Bakhshi, Radhika, Jain, Ayushi, Chopra, Anita, Bakhshi, Sameer
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Biogenesis
Child
DNA Copy Number Variations
DNA, Mitochondrial - genetics
Humans
Leukemia, Myeloid, Acute - genetics
Mitochondrial DNA copy number
MYC
Outcome Assessment, Health Care
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics
PGC1A
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Summary:[Display omitted] •Mitochondrial DNA (mtDNA) copy number is elevated in pediatric AML patients.•Elevated mtDNA copy number predicts aggressive disease and lower survival outcomes.•MtDNA copy number is possibly driven by PGC1A, likely independent of MYC. Mitochondrial DNA (mtDNA) copy number alterations occur in acute myeloid leukemia (AML). We evaluated regulation and biological significance of mtDNA copy number in pediatric AML patients (n = 123) by qRT-PCR, and in-vitro studies. MtDNA copy number was significantly higher (p 
ISSN:1567-7249
1872-8278
DOI:10.1016/j.mito.2021.03.013