Glycemic improvement with a novel interim intervention technique using retrospective professional continuous glucose monitoring (GLITTER study): A study from Mumbai, India

To assess the efficacy of a novel interim intervention technique using retrospective, blinded, professional continuous glucose monitoring system (pro CGM) with the Freestyle Libre Pro system over a 14-day single sensor wear-period. A retrospective analysis comprised of 105 consecutive adults at sing...

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Published in:Diabetes & metabolic syndrome clinical research & reviews 2021-05, Vol.15 (3), p.703-709
Main Author: Jain, Akshay B.
Format: Article
Language:English
Subjects:
Blinded monitoring
Flash glucose monitoring
Hyperglycemia
Hypoglycemia
Professional CGM
Type 2 diabetes
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description To assess the efficacy of a novel interim intervention technique using retrospective, blinded, professional continuous glucose monitoring system (pro CGM) with the Freestyle Libre Pro system over a 14-day single sensor wear-period. A retrospective analysis comprised of 105 consecutive adults at single centre in India with Type 2 diabetes, HbA1c > 53 mmol/mol (>7%), on non-insulin divabetes agents and/or insulin. The interim intervention technique included three visits over 14 days: Visit 1, sensor placed and patients asked to keep a food log while on pro-CGM; Visit 2 (within 1 week), interim assessment of pro CGM and diet or pharmacotherapy modifications made accordingly; Visit 3 at day 14, pro CGM re-evaluated to assess glycemic control. Glucose target range was set at 70–180 mg/dL. Analyses included pre & post daily average glucose, time in range, time above range, and time below range. Average time for interim analysis was 5 days after pro CGM initiation. At Visit 3, daily average glucose decreased from 191.3 mg/dL at baseline to 137.4 mg/dL (p 
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A retrospective analysis comprised of 105 consecutive adults at single centre in India with Type 2 diabetes, HbA1c > 53 mmol/mol (>7%), on non-insulin divabetes agents and/or insulin. The interim intervention technique included three visits over 14 days: Visit 1, sensor placed and patients asked to keep a food log while on pro-CGM; Visit 2 (within 1 week), interim assessment of pro CGM and diet or pharmacotherapy modifications made accordingly; Visit 3 at day 14, pro CGM re-evaluated to assess glycemic control. Glucose target range was set at 70–180 mg/dL. Analyses included pre & post daily average glucose, time in range, time above range, and time below range. Average time for interim analysis was 5 days after pro CGM initiation. At Visit 3, daily average glucose decreased from 191.3 mg/dL at baseline to 137.4 mg/dL (p < 0.001). Time in range improved from 42.2% to 80.2% (p < 0.001). Time above range decreased from 52.1% to 18.3% (p < 0.001), with a concurrent decrease in time below range from 5.7% to 1.5% (p < 0.001). Recurrent hypoglycemia was detected in 27 (25.7%) individuals, whose average baseline time below range reduced from 21.1% to 1.9% (p < 0.001). The interim intervention technique is a cost effective and efficient method for improving glucose outcomes through lifestyle and pharmacotherapy modifications and while utilizing a single pro-CGM sensor. Wockhardt Hospital, Mumbai, India. not applicable due to retrospective chart review study design. •Interim intervention technique using 14-day flash glucose sensing for diabetes care.•Improved daily average glucose and increased time in target range.•Concomitant decrease in time below range and time above range.•Detection of asymptomatic and nocturnal hypoglycemia; education opportunities.•Efficient and cost-effective way to monitor medication & lifestyle changes.]]></description><identifier>ISSN: 1871-4021</identifier><identifier>EISSN: 1878-0334</identifier><identifier>DOI: 10.1016/j.dsx.2021.03.011</identifier><identifier>PMID: 33813245</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Blinded monitoring ; Flash glucose monitoring ; Hyperglycemia ; Hypoglycemia ; Professional CGM ; Type 2 diabetes</subject><ispartof>Diabetes &amp; metabolic syndrome clinical research &amp; reviews, 2021-05, Vol.15 (3), p.703-709</ispartof><rights>2021 Diabetes India</rights><rights>Copyright © 2021 Diabetes India. 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Time above range decreased from 52.1% to 18.3% (p < 0.001), with a concurrent decrease in time below range from 5.7% to 1.5% (p < 0.001). Recurrent hypoglycemia was detected in 27 (25.7%) individuals, whose average baseline time below range reduced from 21.1% to 1.9% (p < 0.001). The interim intervention technique is a cost effective and efficient method for improving glucose outcomes through lifestyle and pharmacotherapy modifications and while utilizing a single pro-CGM sensor. 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Time above range decreased from 52.1% to 18.3% (p < 0.001), with a concurrent decrease in time below range from 5.7% to 1.5% (p < 0.001). Recurrent hypoglycemia was detected in 27 (25.7%) individuals, whose average baseline time below range reduced from 21.1% to 1.9% (p < 0.001). The interim intervention technique is a cost effective and efficient method for improving glucose outcomes through lifestyle and pharmacotherapy modifications and while utilizing a single pro-CGM sensor. Wockhardt Hospital, Mumbai, India. not applicable due to retrospective chart review study design. •Interim intervention technique using 14-day flash glucose sensing for diabetes care.•Improved daily average glucose and increased time in target range.•Concomitant decrease in time below range and time above range.•Detection of asymptomatic and nocturnal hypoglycemia; education opportunities.•Efficient and cost-effective way to monitor medication & lifestyle changes.]]></abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33813245</pmid><doi>10.1016/j.dsx.2021.03.011</doi><tpages>7</tpages></addata></record>
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subjects Blinded monitoring
Flash glucose monitoring
Hyperglycemia
Hypoglycemia
Professional CGM
Type 2 diabetes
title Glycemic improvement with a novel interim intervention technique using retrospective professional continuous glucose monitoring (GLITTER study): A study from Mumbai, India
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