The characteristics of carotid body tumors in high-altitude region: Analysis from a single center

Objectives Though carotid body tumors are rare, increasing attentions have been given because of malignant transformation and high surgical risk. However, at present, the characteristics and etiology still remain unclear. Our study was designed to describe the clinical features of carotid body tumor...

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Published in:Vascular 2022-04, Vol.30 (2), p.301-309
Main Authors: Wang, Yong-Hong, Zhu, Ji-Hai, Yang, Jia, Ma, Wei, Zhong, Hao, Zhang, Wen-Shi, Wu, Jian-Ying
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container_title Vascular
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Zhu, Ji-Hai
Yang, Jia
Ma, Wei
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description Objectives Though carotid body tumors are rare, increasing attentions have been given because of malignant transformation and high surgical risk. However, at present, the characteristics and etiology still remain unclear. Our study was designed to describe the clinical features of carotid body tumors in our institution and to compare the results with previous reports. Methods We retrospectively reviewed carotid body tumor patients diagnosed in our institution from January 2015 to May 2020. The demographics, comorbidities, lesion location, anatomic characteristics, complications, and postoperative outcomes were evaluated. Carotid body tumor measurements were determined from computed tomography, magnetic resonance imaging, and carotid arteriography examination. We described and compared the clinical features of carotid body tumors in our institution and other reports. Results We totally identified 122 carotid body tumor cases for the present analysis. The mean age was 50.26 years, with the majority being female (82%). The commonest presentation was a painless neck mass (68%). For the distribution of nationality, most patients were the Han nationality (69.7%). The mean altitude of habitat of patients was 2689.4 km; 19.7% patients suffered bilateral lesions. The main blood supply of carotid body tumors was from external carotid artery (54.1%). For patients who received operation, 11 (11.2%) patients experienced cranial nerve injury. The maximal diameter of tumors was 3.99 ± 1.98 cm in male and 3.38 ± 1.36 cm in female. The volume of tumors was 31.49 ± 29.76 cm3 in male and 15.27 ± 13.06 cm3 in female. The distance to base of skull of tumors was 3.39 ± 1.07 cm (3.99 ± 1.98 cm in male vs 3.38 ± 1.36 cm, P 
doi_str_mv 10.1177/17085381211005238
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However, at present, the characteristics and etiology still remain unclear. Our study was designed to describe the clinical features of carotid body tumors in our institution and to compare the results with previous reports. Methods We retrospectively reviewed carotid body tumor patients diagnosed in our institution from January 2015 to May 2020. The demographics, comorbidities, lesion location, anatomic characteristics, complications, and postoperative outcomes were evaluated. Carotid body tumor measurements were determined from computed tomography, magnetic resonance imaging, and carotid arteriography examination. We described and compared the clinical features of carotid body tumors in our institution and other reports. Results We totally identified 122 carotid body tumor cases for the present analysis. The mean age was 50.26 years, with the majority being female (82%). The commonest presentation was a painless neck mass (68%). For the distribution of nationality, most patients were the Han nationality (69.7%). The mean altitude of habitat of patients was 2689.4 km; 19.7% patients suffered bilateral lesions. The main blood supply of carotid body tumors was from external carotid artery (54.1%). For patients who received operation, 11 (11.2%) patients experienced cranial nerve injury. The maximal diameter of tumors was 3.99 ± 1.98 cm in male and 3.38 ± 1.36 cm in female. The volume of tumors was 31.49 ± 29.76 cm3 in male and 15.27 ± 13.06 cm3 in female. The distance to base of skull of tumors was 3.39 ± 1.07 cm (3.99 ± 1.98 cm in male vs 3.38 ± 1.36 cm, P &lt; 0.05). Two patients (2.04%) were identified as having malignant carotid body tumor. Conclusions Though carotid body tumor had a low morbidity and multitudinous clinicopathologic features, it was apt to middle-aged women and the main blood supply was from external carotid artery. The painless neck mass was the commonest presentation of carotid body tumors. There were significant difference between male and female patients regarding platelet, hemoglobin, distance to base of skull, tumor volume, altitude of habitat, carotid body tumor location, and hypertension.</description><identifier>ISSN: 1708-5381</identifier><identifier>EISSN: 1708-539X</identifier><identifier>DOI: 10.1177/17085381211005238</identifier><identifier>PMID: 33813973</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>Vascular, 2022-04, Vol.30 (2), p.301-309</ispartof><rights>The Author(s) 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-a03955d1d9472bb7deb44e62698a6f1b4ef95aca34692eb7329060083b89b2f03</citedby><cites>FETCH-LOGICAL-c340t-a03955d1d9472bb7deb44e62698a6f1b4ef95aca34692eb7329060083b89b2f03</cites><orcidid>0000-0001-7758-4225</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906,79113</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33813973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yong-Hong</creatorcontrib><creatorcontrib>Zhu, Ji-Hai</creatorcontrib><creatorcontrib>Yang, Jia</creatorcontrib><creatorcontrib>Ma, Wei</creatorcontrib><creatorcontrib>Zhong, Hao</creatorcontrib><creatorcontrib>Zhang, Wen-Shi</creatorcontrib><creatorcontrib>Wu, Jian-Ying</creatorcontrib><title>The characteristics of carotid body tumors in high-altitude region: Analysis from a single center</title><title>Vascular</title><addtitle>Vascular</addtitle><description>Objectives Though carotid body tumors are rare, increasing attentions have been given because of malignant transformation and high surgical risk. However, at present, the characteristics and etiology still remain unclear. Our study was designed to describe the clinical features of carotid body tumors in our institution and to compare the results with previous reports. Methods We retrospectively reviewed carotid body tumor patients diagnosed in our institution from January 2015 to May 2020. The demographics, comorbidities, lesion location, anatomic characteristics, complications, and postoperative outcomes were evaluated. Carotid body tumor measurements were determined from computed tomography, magnetic resonance imaging, and carotid arteriography examination. We described and compared the clinical features of carotid body tumors in our institution and other reports. Results We totally identified 122 carotid body tumor cases for the present analysis. The mean age was 50.26 years, with the majority being female (82%). The commonest presentation was a painless neck mass (68%). For the distribution of nationality, most patients were the Han nationality (69.7%). The mean altitude of habitat of patients was 2689.4 km; 19.7% patients suffered bilateral lesions. The main blood supply of carotid body tumors was from external carotid artery (54.1%). For patients who received operation, 11 (11.2%) patients experienced cranial nerve injury. The maximal diameter of tumors was 3.99 ± 1.98 cm in male and 3.38 ± 1.36 cm in female. The volume of tumors was 31.49 ± 29.76 cm3 in male and 15.27 ± 13.06 cm3 in female. The distance to base of skull of tumors was 3.39 ± 1.07 cm (3.99 ± 1.98 cm in male vs 3.38 ± 1.36 cm, P &lt; 0.05). Two patients (2.04%) were identified as having malignant carotid body tumor. Conclusions Though carotid body tumor had a low morbidity and multitudinous clinicopathologic features, it was apt to middle-aged women and the main blood supply was from external carotid artery. The painless neck mass was the commonest presentation of carotid body tumors. There were significant difference between male and female patients regarding platelet, hemoglobin, distance to base of skull, tumor volume, altitude of habitat, carotid body tumor location, and hypertension.</description><issn>1708-5381</issn><issn>1708-539X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAUhS0EoqXwA1iQR5aAH3nYbFXFS6rEUiS2yE6c1FUSF19n6L_HVUsXJKZ7dXTON3wI3VLyQGlRPNKCiIwLyiglJGNcnKHpPksyLr_OT7-gE3QFsCGEE0bzSzThMeOy4FOkVmuDq7XyqgrGWwi2AuwaXCnvgq2xdvUOh7F3HrAd8Nq260R1wYaxNtib1rrhCc8H1e3AAm6867HCYIe2i1gzROY1umhUB-bmeGfo8-V5tXhLlh-v74v5Mql4SkKiCJdZVtNapgXTuqiNTlOTs1wKlTdUp6aRmaoUT3PJjC44kyQnRHAtpGYN4TN0f-BuvfseDYSyt1CZrlODcSOULCNCCBmFxSo9VCvvALxpyq23vfK7kpJyb7b8YzZu7o74UfemPi1-VcbCw6EAqjXlxo0-WoF_iD8ntYCO</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Wang, Yong-Hong</creator><creator>Zhu, Ji-Hai</creator><creator>Yang, Jia</creator><creator>Ma, Wei</creator><creator>Zhong, Hao</creator><creator>Zhang, Wen-Shi</creator><creator>Wu, Jian-Ying</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7758-4225</orcidid></search><sort><creationdate>20220401</creationdate><title>The characteristics of carotid body tumors in high-altitude region: Analysis from a single center</title><author>Wang, Yong-Hong ; Zhu, Ji-Hai ; Yang, Jia ; Ma, Wei ; Zhong, Hao ; Zhang, Wen-Shi ; Wu, Jian-Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-a03955d1d9472bb7deb44e62698a6f1b4ef95aca34692eb7329060083b89b2f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yong-Hong</creatorcontrib><creatorcontrib>Zhu, Ji-Hai</creatorcontrib><creatorcontrib>Yang, Jia</creatorcontrib><creatorcontrib>Ma, Wei</creatorcontrib><creatorcontrib>Zhong, Hao</creatorcontrib><creatorcontrib>Zhang, Wen-Shi</creatorcontrib><creatorcontrib>Wu, Jian-Ying</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vascular</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yong-Hong</au><au>Zhu, Ji-Hai</au><au>Yang, Jia</au><au>Ma, Wei</au><au>Zhong, Hao</au><au>Zhang, Wen-Shi</au><au>Wu, Jian-Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The characteristics of carotid body tumors in high-altitude region: Analysis from a single center</atitle><jtitle>Vascular</jtitle><addtitle>Vascular</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>30</volume><issue>2</issue><spage>301</spage><epage>309</epage><pages>301-309</pages><issn>1708-5381</issn><eissn>1708-539X</eissn><abstract>Objectives Though carotid body tumors are rare, increasing attentions have been given because of malignant transformation and high surgical risk. However, at present, the characteristics and etiology still remain unclear. Our study was designed to describe the clinical features of carotid body tumors in our institution and to compare the results with previous reports. Methods We retrospectively reviewed carotid body tumor patients diagnosed in our institution from January 2015 to May 2020. The demographics, comorbidities, lesion location, anatomic characteristics, complications, and postoperative outcomes were evaluated. Carotid body tumor measurements were determined from computed tomography, magnetic resonance imaging, and carotid arteriography examination. We described and compared the clinical features of carotid body tumors in our institution and other reports. Results We totally identified 122 carotid body tumor cases for the present analysis. The mean age was 50.26 years, with the majority being female (82%). The commonest presentation was a painless neck mass (68%). For the distribution of nationality, most patients were the Han nationality (69.7%). The mean altitude of habitat of patients was 2689.4 km; 19.7% patients suffered bilateral lesions. The main blood supply of carotid body tumors was from external carotid artery (54.1%). For patients who received operation, 11 (11.2%) patients experienced cranial nerve injury. The maximal diameter of tumors was 3.99 ± 1.98 cm in male and 3.38 ± 1.36 cm in female. The volume of tumors was 31.49 ± 29.76 cm3 in male and 15.27 ± 13.06 cm3 in female. The distance to base of skull of tumors was 3.39 ± 1.07 cm (3.99 ± 1.98 cm in male vs 3.38 ± 1.36 cm, P &lt; 0.05). Two patients (2.04%) were identified as having malignant carotid body tumor. Conclusions Though carotid body tumor had a low morbidity and multitudinous clinicopathologic features, it was apt to middle-aged women and the main blood supply was from external carotid artery. The painless neck mass was the commonest presentation of carotid body tumors. There were significant difference between male and female patients regarding platelet, hemoglobin, distance to base of skull, tumor volume, altitude of habitat, carotid body tumor location, and hypertension.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33813973</pmid><doi>10.1177/17085381211005238</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-7758-4225</orcidid></addata></record>
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title The characteristics of carotid body tumors in high-altitude region: Analysis from a single center
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