Significance of Plasma UCA1 for Predicting Colorectal Cancer and BRAF Mutation Status

Clinical significance of plasma urothelial carcinoma associated 1 (UCA1) in patients with colorectal cancer (CRC) remains unclear. This study investigated the usefulness of plasma UCA1 as a biomarker in patients with CRC. UCA1 levels were measured in the plasma and tissue from patients with CRC by q...

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Bibliographic Details
Published in:Anticancer research 2021-04, Vol.41 (4), p.1761-1769
Main Authors: Maeda, Tomohito, Konishi, Hirotaka, Takaki, Wataru, Takabatake, Kazuya, Matsubara, Daiki, Shoda, Katsutoshi, Arita, Tomohiro, Shimizu, Hiroki, Komatsu, Shuhei, Shiozaki, Atsushi, Kuriu, Yoshiaki, Otsuji, Eigo
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Cancer
Case-Control Studies
Cell-Free Nucleic Acids - blood
Cell-Free Nucleic Acids - genetics
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - blood
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Female
Genetic Predisposition to Disease
Humans
Kinases
Male
Middle Aged
Mutation
Neoplasm Staging
Phenotype
Plasma
Polymerase chain reaction
Protein-serine/threonine kinase
Proto-Oncogene Proteins B-raf - genetics
RNA, Long Noncoding - blood
RNA, Long Noncoding - genetics
Tissues
Urothelial carcinoma
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Summary:Clinical significance of plasma urothelial carcinoma associated 1 (UCA1) in patients with colorectal cancer (CRC) remains unclear. This study investigated the usefulness of plasma UCA1 as a biomarker in patients with CRC. UCA1 levels were measured in the plasma and tissue from patients with CRC by quantitative polymerase chain reaction. Relationships between plasma UCA1 and clinicopathological features were examined. Plasma UCA1 levels were significantly lower in patients with CRC than in healthy volunteers. UCA1 expression in B-Raf proto-oncogene serine/threonine kinase (BRAF)-mutant CRC tissue was also lower than that in non-cancerous tissue, although it was higher in CRC with wild-type BRAF. In right-sided CRC, a lower plasma UCA1 level was associated with pT4 and BRAF mutation. In contrast, in left-sided CRC, higher plasma UCA1 was associated with pT4 and pStage 3b-4. Plasma UCA1 is a useful biomarker for CRC detection and predicting clinicopathological features, particularly BRAF mutation.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.14941