Assessment of ocular blood flow in continuous-flow ventricular assist device by laser speckle flowgraphy

Although the influence of continuous-flow left ventricular assist device (CF-LVAD) support on peripheral circulation has been widely discussed, its monitoring modalities are limited. The aim of this study was to assess the peripheral circulation using the laser speckle flowgraph (LSFG) which can qua...

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Bibliographic Details
Published in:Journal of artificial organs 2021-12, Vol.24 (4), p.419-424
Main Authors: Shimamura, Junichi, Nishinaka, Tomohiro, Mizuno, Toshihide, Tsukiya, Tomonori, Inatomi, Ayako, Kobayashi, Futoshi, Katagiri, Nobumasa, Takewa, Yoshiaki, Nishimura, Takashi, Ono, Minoru, Tatsumi, Eisuke
Format: Article
Language:English
Subjects:
Anesthesia
Animals
Biomedical Engineering and Bioengineering
Blood flow
Blood Flow Velocity
Body weight
Cardiac Surgery
Carotid arteries
Carotid artery
Eye - blood supply
Fluctuations
Goats
Heart
Heart-Assist Devices
Hemodynamics
Implantation
Laser-Doppler Flowmetry
Lasers
Medical research
Medical technology
Medicine
Medicine & Public Health
Nephrology
Original Article
Peripheral circulation
Regional Blood Flow
Retina
Veins & arteries
Ventricle
Waveforms
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Summary:Although the influence of continuous-flow left ventricular assist device (CF-LVAD) support on peripheral circulation has been widely discussed, its monitoring modalities are limited. The aim of this study was to assess the peripheral circulation using the laser speckle flowgraph (LSFG) which can quantitatively measure the ocular blood flow. We implanted a centrifugal CF-LVAD (EVAHEART ® ; Sun Medical Technology Research Corporation, Nagano, Japan) in five adult goats (body weight 44.5 ± 2.9 kg) under general anesthesia. The waveform of the central retinal artery using the mean blur rate (MBR) for ocular blood velocity and fluctuations as a parameter of pulsatility were obtained before LVAD implantation and after LVAD full-bypass support. The MBR waveform and LSFG fluctuation data were compared with the waveform and pulsatility index of the external carotid artery using an ultrasonic flow meter to evaluate circulatory patterns at different levels. The MBR waveform pattern of the central retinal artery was pulsatile before LVAD implantation and less pulsatile under LVAD full bypass. The fluctuation was 14.7 ± 1.86 before LVAD implantation and 3.85 ± 0.61 under LVAD full bypass ( p  
ISSN:1434-7229
1619-0904
DOI:10.1007/s10047-021-01265-5