Value of [68Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

Purpose Renal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolonging patient survival. Renal puncture examination is the gold standard for renal fibrosis, but it has several limitations. This study aims to evaluate the dia...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2021-10, Vol.48 (11), p.3493-3501
Main Authors: Zhou, Yue, Yang, Xin, Liu, Huipan, Luo, Wenbin, Liu, Hanxiang, Lv, Taiyong, Wang, Junzheng, Qin, Jianhua, Ou, Santao, Chen, Yue
Format: Article
Language:English
Subjects:
Cardiology
Computed tomography
Diagnosis
Fibroblast activation protein
Fibroblasts
Fibrosis
Imaging
Kidney diseases
Medical diagnosis
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Original Article
Orthopedics
Patients
Performance evaluation
Positron emission
Proteins
Radioactive tracers
Radiology
Radiopharmacy
Tomography
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Summary:Purpose Renal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolonging patient survival. Renal puncture examination is the gold standard for renal fibrosis, but it has several limitations. This study aims to evaluate the diagnostic performance of a novel PET radiotracer, [ 68 Ga]Ga-fibroblast activation protein inhibitor (FAPI)-04, which specifically images fibroblast activation protein (FAP) expression for renal fibrosis. Methods All patients underwent renal puncture before receiving [ 68 Ga]Ga-FAPI-04 PET/CT imaging. They then underwent [ 68 Ga]Ga-FAPI-04 PET/CT and immunochemistry examinations. The data obtained were analyzed. Results The [ 68 Ga]Ga-FAPI-04 PET/CT examination results demonstrated that almost all patients (12/13) exhibited increased radiotracer uptake. The maximum standardized uptake value (SUVmax) in patients with mild, moderate, and severe fibrosis was 3.92 ± 1.50, 5.98 ± 1.6, and 7.67 ± 2.23, respectively. Conclusion Compared with renal puncture examination, non-invasive imaging of FAP expression through [ 68 Ga]Ga-FAPI-04 PET/CT quickly demonstrates bilateral kidney conditions with high sensitivity. [ 68 Ga]Ga-FAPI-04 PET/CT can facilitate the evaluation of disease progression, diagnosis, and the development of a treatment plan.
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-021-05343-x