Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos

Two unprecedented tetranorlanostane triterpenoids, poricolides A (1) and B (2), and two new lanostane triterpenoids, 3β‐acetoxy‐24‐methyllanosta‐8,16,24(31)‐trien‐21‐oic acid (3) and 3β‐acetoxylanosta‐7,9(11),16,23‐tetraen‐21‐oic acid (4), were isolated from the epidermis of Poria cocos. The structu...

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Bibliographic Details
Published in:Chemistry & biodiversity 2021-05, Vol.18 (5), p.e2100196-n/a
Main Authors: Jiang, Ting‐Ting, Ding, Lin‐Fen, Nie, Wei, Wang, Liu‐Yan, Lei, Tie, Wu, Xing‐De, Zhao, Qin‐Shi
Format: Article
Language:English
Subjects:
cytotoxic activity
Cytotoxicity
Epidermis
lanostane triterpenoid
NMR
Nuclear magnetic resonance
Poria cocos
tetranorlanostane triterpenoid
Triterpenoids
Tumor cell lines
Two dimensional analysis
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Summary:Two unprecedented tetranorlanostane triterpenoids, poricolides A (1) and B (2), and two new lanostane triterpenoids, 3β‐acetoxy‐24‐methyllanosta‐8,16,24(31)‐trien‐21‐oic acid (3) and 3β‐acetoxylanosta‐7,9(11),16,23‐tetraen‐21‐oic acid (4), were isolated from the epidermis of Poria cocos. The structures of 1–4 were determined via analysis of 1H‐, 13C‐, and 2D‐NMR, and HR‐ESI‐MS data, and the absolute configurations of 1 and 3 were established by single‐crystal X‐ray diffraction analysis. Compounds 1 and 2 were the first report of tetranorlanostane triterpenoid having a δ‐lactone ring at C(17). Compounds 3 and 4 were rare lanostane triterpenoids having a double bond between C(16) and C(17). Compounds 1–4 exhibited potent antiproliferative effects against A549, SMMC‐7721, MCF‐7, and SW480 cancer cell lines with IC50 values from 16.19±0.38 to 27.74±1.12 μM.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202100196