Pre-micro RNA polymorphism detection in small versus large vessel disease in stroke Egyptian patients

Stroke is the main cause of adult disability and is responsible for around 11% of deaths all over the world. Ischemic stroke encompasses about 80–85% of total stroke cases. Several studies have shown the relation between microRNAs polymorphism and ischemic stroke. The aim of the study was to evaluat...

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Bibliographic Details
Published in:Metabolic brain disease 2021-08, Vol.36 (6), p.1361-1367
Main Authors: Hassan, Ekrami A., El-Khawas, Hala M., H., Afify, Alzahaby, Alaa A., Elbakry, Mustafa M. M., Shokri, Hossam M.
Format: Article
Language:English
Subjects:
Aged
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cerebral Small Vessel Diseases - diagnostic imaging
Cerebral Small Vessel Diseases - epidemiology
Cerebral Small Vessel Diseases - genetics
Cerebrovascular Disorders - diagnostic imaging
Cerebrovascular Disorders - epidemiology
Cerebrovascular Disorders - genetics
Cross-Sectional Studies
Diuretics
Echocardiography
Egypt - epidemiology
Electrocardiography
Female
Genetic Predisposition to Disease
Health risks
Humans
Ischemia
Ischemic Stroke - diagnostic imaging
Ischemic Stroke - epidemiology
Ischemic Stroke - genetics
Magnetic Resonance Imaging
Male
Metabolic Diseases
MicroRNAs - genetics
Middle Aged
miRNA
Neurology
Neurosciences
Nucleotides
Oncology
Original Article
Polymorphism
Polymorphism, Genetic - genetics
Risk
Single-nucleotide polymorphism
Stroke
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Summary:Stroke is the main cause of adult disability and is responsible for around 11% of deaths all over the world. Ischemic stroke encompasses about 80–85% of total stroke cases. Several studies have shown the relation between microRNAs polymorphism and ischemic stroke. The aim of the study was to evaluate the influence of three common single nucleotide polymorphisms in pre-miRNAs (hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444) on individual susceptibility to the risk of ischemic stroke subtypes in Egyptian population with 117 ischemic stroke patients. Results showed that hsa-miR-146a/rs2910164 was significantly associated with the risk of small vessel disease stroke in Egyptian population with no significant association between hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444 with the risk of ischemic stroke. Therefore, it can be concluded that miR-146a/rs2910164 polymorphism is involved in the vulnerability to small vessel disease ischemic stroke risk in Egyptian population.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-021-00723-6