The role of polymorphisms rs2070744 and rs1799983 eNOS gene in patients with POAG: a systematic review and meta-analysis

• Published in: International ophthalmology 2021-08, Vol.41 (8), p.2747-2763
• Main Authors: Salari, Nader, Bokaee, Shadi, Farshchian, Nushin, Mohammadi, Masoud, Kazeminia, Mohsen
• Format: Article
• Language: English
• Subjects: Case-Control Studies; Data analysis; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Genotypes; Glaucoma; Glaucoma, Open-Angle - genetics; Humans; Medicine; Medicine & Public Health; Meta-analysis; Nitric oxide; Ophthalmology; Optic nerve; Original Paper; Polymorphism; Polymorphism, Single Nucleotide; Search engines; Systematic review
• ISSN: 0165-5701; 1573-2630
• DOI: 10.1007/s10792-021-01832-y

Background Glaucoma is a progressive disease of the optic nerve that has several underlying causes, but in most cases, the cause is unknown. Given the importance of the role of nitric oxide in the occurrence of ocular nerve damage and the effect of eNOS gene polymorphic sites on protein function, to better understand the mechanism of formation of POAG, the relationship between polymorphisms rs2070744 and rs1799983 eNOS gene with POAG risk was investigated in this study using meta-analysis. Methods In this study, systematic review and meta-analysis of study data related to the study of polymorphisms rs2070744 and rs1799983 eNOS gene in patients with POAG using the keywords eNOS, NOS3, Gluuc8898, POAG, primary open-angle glaucoma. It was extracted from SID, MagIran, IranMedex, IranDoc, ScienceDirect, Embase, Scopus, PubMed, Web of Science, and Google Scholar search engines without a time limit until May 2020. To perform the analysis of qualified studies, the model of random effects was used and the inconsistency of studies with the I 2 index was investigated. Data analysis was performed with Comprehensive Meta-Analysis (Version 2). Results In a review of 16 studies (9 studies on polymorphism rs2070744 and seven studies on polymorphism rs1799983) with a sample size of 1631 subjects and a control group of 2405 subjects related to polymorphism rs2070744 and a group of 1456 subjects and a control group of 2240 subjects related to polymorphism 9997 rs1, the odds ratio of TT, CT, and CC genotypes was reported to be 0.95, 1.01, and 1.14, respectively, and the odds ratio of GG, GT and TT genotypes to be 0.88, 0.97, and 1.31, respectively, was reported in patients with POAG. Conclusion The results of our systematic review and meta-analysis study show that the eNOS gene polymorphisms rs2070744 and rs1799983 may increase the risk of POAG among individuals. However, further studies are needed to confirm these findings.