Anterior‐segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction

• Published in: Acta ophthalmologica (Oxford, England) England), 2022-02, Vol.100 (1), p.e192-e203
• Main Authors: Ibarz Barberá, Marta, Morales Fernández, Laura, Tañá Rivero, Pedro, Gómez de Liaño, Rosario, Teus, Miguel A.
• Format: Article
• Language: English
• Subjects: Aged; Anterior Eye Segment - diagnostic imaging; AS‐OCT; Bleb; Cross-Linking Reagents - administration & dosage; Drug Implants - administration & dosage; Female; Filtering Surgery - methods; Follow-Up Studies; Glaucoma; Glaucoma, Open-Angle - diagnosis; Glaucoma, Open-Angle - physiopathology; Glaucoma, Open-Angle - therapy; Humans; Intraocular Pressure - physiology; IOP; Male; MIGS; Mitomycin - administration & dosage; Mitomycin C; Morphology; POAG; Postoperative Period; PRESERFLO; Pressure; Prospective Studies; Tomography, Optical Coherence - methods
• ISSN: 1755-375X; 1755-3768
• DOI: 10.1111/aos.14863

Purpose To analyse the morphological evolution of filtering blebs with anterior‐segment OCT (AS‐OCT) and its correlation with intraocular pressure after ab externo SIBS microshunt implantation with mitomycin C (MMC) during a 3‐month follow‐up period. Methods Twenty‐eight filtering blebs of 28 patients with open‐angle glaucoma were measured horizontally and vertically in the sub‐Tenon space with AS‐OCT after ab externo SIBS microshunt implantation with MMC. The intraocular pressure (IOP) was monitored simultaneously at each visit. Maturation of and morphological changes in the blebs and correlations with the IOP were recorded. Results The average median preoperative IOP of 20.7 (range, 12–30) mmHg decreased to 8.5 (range, 4–17), 8.9 (range, 5–17), 10.4 (range, 8–16) and 10.9 (range, 9–15) mmHg at 24 hr, 1 week, 1 month and 3 months, respectively (p