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Anterior‐segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction
Purpose To analyse the morphological evolution of filtering blebs with anterior‐segment OCT (AS‐OCT) and its correlation with intraocular pressure after ab externo SIBS microshunt implantation with mitomycin C (MMC) during a 3‐month follow‐up period. Methods Twenty‐eight filtering blebs of 28 patien...
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| Published in: | Acta ophthalmologica (Oxford, England) England), 2022-02, Vol.100 (1), p.e192-e203 |
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| container_title | Acta ophthalmologica (Oxford, England) |
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| creator | Ibarz Barberá, Marta Morales Fernández, Laura Tañá Rivero, Pedro Gómez de Liaño, Rosario Teus, Miguel A. |
| description | Purpose
To analyse the morphological evolution of filtering blebs with anterior‐segment OCT (AS‐OCT) and its correlation with intraocular pressure after ab externo SIBS microshunt implantation with mitomycin C (MMC) during a 3‐month follow‐up period.
Methods
Twenty‐eight filtering blebs of 28 patients with open‐angle glaucoma were measured horizontally and vertically in the sub‐Tenon space with AS‐OCT after ab externo SIBS microshunt implantation with MMC. The intraocular pressure (IOP) was monitored simultaneously at each visit. Maturation of and morphological changes in the blebs and correlations with the IOP were recorded.
Results
The average median preoperative IOP of 20.7 (range, 12–30) mmHg decreased to 8.5 (range, 4–17), 8.9 (range, 5–17), 10.4 (range, 8–16) and 10.9 (range, 9–15) mmHg at 24 hr, 1 week, 1 month and 3 months, respectively (p |
| doi_str_mv | 10.1111/aos.14863 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2511237105</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2511237105</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3883-231af02e779aac3476f5218dd7ebdc61aad36c220420ee665bf03ea7f8486fb3</originalsourceid><addsrcrecordid>eNp1ksFu1DAQhiMEoqVw4AWQJS70sK0dJ47htqwKVCrqYXvgFjnOZOPKscPYacmNR-AZOfMQON1SISR88Uj-_n9mPJNlLxk9YemcKh9OWCEFf5QdsqosV7wS8vFDXH45yJ6FcE2pYEIUT7MDziWXNGeH2a-1i4DG48_vPwLsBnCR-DEarSzRvgcEp4FEP_gdqrGfie9IZ-yicTvSWGgCMY7EHggotDMZfYh-BFTR3AAZF-92EamGwLckc55sz99vyWA0-tBPKZ8ZRqtcTArvyK2JfXpMGWedjDfvyGePY--t390VpZyyczAhBW2qEBHsX0LjIiqvJ6uQjAghTAgEoZ30wjzPnnTKBnhxfx9lVx_OrjafVheXH88364uV5lLyVc6Z6mgOVfVWKc2LSnRlzmTbVtC0WjClWi50ntMipwBClE1HOaiqk2kGXcOPsjd72xH91wlCrAcTNNjUJPgp1HnJWM4rRsuEvv4HvfYTphYTJZhkBSupTNTxnlq-LCB09YhmUDjXjNbLBtRpA-q7DUjsq3vHqRmgfSD_jDwBp3vg1liY_-9Ury-3e8vfVlLDbQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2618141508</pqid></control><display><type>article</type><title>Anterior‐segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction</title><source>Wiley</source><creator>Ibarz Barberá, Marta ; Morales Fernández, Laura ; Tañá Rivero, Pedro ; Gómez de Liaño, Rosario ; Teus, Miguel A.</creator><creatorcontrib>Ibarz Barberá, Marta ; Morales Fernández, Laura ; Tañá Rivero, Pedro ; Gómez de Liaño, Rosario ; Teus, Miguel A.</creatorcontrib><description>Purpose
To analyse the morphological evolution of filtering blebs with anterior‐segment OCT (AS‐OCT) and its correlation with intraocular pressure after ab externo SIBS microshunt implantation with mitomycin C (MMC) during a 3‐month follow‐up period.
Methods
Twenty‐eight filtering blebs of 28 patients with open‐angle glaucoma were measured horizontally and vertically in the sub‐Tenon space with AS‐OCT after ab externo SIBS microshunt implantation with MMC. The intraocular pressure (IOP) was monitored simultaneously at each visit. Maturation of and morphological changes in the blebs and correlations with the IOP were recorded.
Results
The average median preoperative IOP of 20.7 (range, 12–30) mmHg decreased to 8.5 (range, 4–17), 8.9 (range, 5–17), 10.4 (range, 8–16) and 10.9 (range, 9–15) mmHg at 24 hr, 1 week, 1 month and 3 months, respectively (p < 0.001). A multiform morphology on AS‐OCT prevailed at all time points, with a 3.5% rate of a uniform bleb morphology at the first week. The horizontal and vertical diameters of the blebs increased from baseline to the third month. The horizontal expansion (406 ± 127 μm on day 7, p = 0.04, 712 ± 211 μm on day 30, p = 0.02 and 952 ± 218 μm on day 90, p < 0.001) was greater than the vertical expansion (16 ± 18 μm, p = 0.3 on day 1, 63 ± 27 μm, p = 0.02 on day 30 and 137 ± 34 μm, p < 0.001 on day 90) without correlation with the IOP (r = −0.3, p = 0.2).
Conclusion
Anterior‐segment OCT (AS‐OCT) of the filtering blebs formed after ab externo SIBS microshunt implantation showed progressive horizontal and vertical expansion of the blebs in the sub‐Tenon space, with a significant peak at the first month not significantly correlated with the decrease in the IOP.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.14863</identifier><identifier>PMID: 33838021</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Anterior Eye Segment - diagnostic imaging ; AS‐OCT ; Bleb ; Cross-Linking Reagents - administration & dosage ; Drug Implants - administration & dosage ; Female ; Filtering Surgery - methods ; Follow-Up Studies ; Glaucoma ; Glaucoma, Open-Angle - diagnosis ; Glaucoma, Open-Angle - physiopathology ; Glaucoma, Open-Angle - therapy ; Humans ; Intraocular Pressure - physiology ; IOP ; Male ; MIGS ; Mitomycin - administration & dosage ; Mitomycin C ; Morphology ; POAG ; Postoperative Period ; PRESERFLO ; Pressure ; Prospective Studies ; Tomography, Optical Coherence - methods</subject><ispartof>Acta ophthalmologica (Oxford, England), 2022-02, Vol.100 (1), p.e192-e203</ispartof><rights>2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2022 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-231af02e779aac3476f5218dd7ebdc61aad36c220420ee665bf03ea7f8486fb3</citedby><cites>FETCH-LOGICAL-c3883-231af02e779aac3476f5218dd7ebdc61aad36c220420ee665bf03ea7f8486fb3</cites><orcidid>0000-0002-7776-504X ; 0000-0002-6182-0753</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33838021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ibarz Barberá, Marta</creatorcontrib><creatorcontrib>Morales Fernández, Laura</creatorcontrib><creatorcontrib>Tañá Rivero, Pedro</creatorcontrib><creatorcontrib>Gómez de Liaño, Rosario</creatorcontrib><creatorcontrib>Teus, Miguel A.</creatorcontrib><title>Anterior‐segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To analyse the morphological evolution of filtering blebs with anterior‐segment OCT (AS‐OCT) and its correlation with intraocular pressure after ab externo SIBS microshunt implantation with mitomycin C (MMC) during a 3‐month follow‐up period.
Methods
Twenty‐eight filtering blebs of 28 patients with open‐angle glaucoma were measured horizontally and vertically in the sub‐Tenon space with AS‐OCT after ab externo SIBS microshunt implantation with MMC. The intraocular pressure (IOP) was monitored simultaneously at each visit. Maturation of and morphological changes in the blebs and correlations with the IOP were recorded.
Results
The average median preoperative IOP of 20.7 (range, 12–30) mmHg decreased to 8.5 (range, 4–17), 8.9 (range, 5–17), 10.4 (range, 8–16) and 10.9 (range, 9–15) mmHg at 24 hr, 1 week, 1 month and 3 months, respectively (p < 0.001). A multiform morphology on AS‐OCT prevailed at all time points, with a 3.5% rate of a uniform bleb morphology at the first week. The horizontal and vertical diameters of the blebs increased from baseline to the third month. The horizontal expansion (406 ± 127 μm on day 7, p = 0.04, 712 ± 211 μm on day 30, p = 0.02 and 952 ± 218 μm on day 90, p < 0.001) was greater than the vertical expansion (16 ± 18 μm, p = 0.3 on day 1, 63 ± 27 μm, p = 0.02 on day 30 and 137 ± 34 μm, p < 0.001 on day 90) without correlation with the IOP (r = −0.3, p = 0.2).
Conclusion
Anterior‐segment OCT (AS‐OCT) of the filtering blebs formed after ab externo SIBS microshunt implantation showed progressive horizontal and vertical expansion of the blebs in the sub‐Tenon space, with a significant peak at the first month not significantly correlated with the decrease in the IOP.</description><subject>Aged</subject><subject>Anterior Eye Segment - diagnostic imaging</subject><subject>AS‐OCT</subject><subject>Bleb</subject><subject>Cross-Linking Reagents - administration & dosage</subject><subject>Drug Implants - administration & dosage</subject><subject>Female</subject><subject>Filtering Surgery - methods</subject><subject>Follow-Up Studies</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - diagnosis</subject><subject>Glaucoma, Open-Angle - physiopathology</subject><subject>Glaucoma, Open-Angle - therapy</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>IOP</subject><subject>Male</subject><subject>MIGS</subject><subject>Mitomycin - administration & dosage</subject><subject>Mitomycin C</subject><subject>Morphology</subject><subject>POAG</subject><subject>Postoperative Period</subject><subject>PRESERFLO</subject><subject>Pressure</subject><subject>Prospective Studies</subject><subject>Tomography, Optical Coherence - methods</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1ksFu1DAQhiMEoqVw4AWQJS70sK0dJ47htqwKVCrqYXvgFjnOZOPKscPYacmNR-AZOfMQON1SISR88Uj-_n9mPJNlLxk9YemcKh9OWCEFf5QdsqosV7wS8vFDXH45yJ6FcE2pYEIUT7MDziWXNGeH2a-1i4DG48_vPwLsBnCR-DEarSzRvgcEp4FEP_gdqrGfie9IZ-yicTvSWGgCMY7EHggotDMZfYh-BFTR3AAZF-92EamGwLckc55sz99vyWA0-tBPKZ8ZRqtcTArvyK2JfXpMGWedjDfvyGePY--t390VpZyyczAhBW2qEBHsX0LjIiqvJ6uQjAghTAgEoZ30wjzPnnTKBnhxfx9lVx_OrjafVheXH88364uV5lLyVc6Z6mgOVfVWKc2LSnRlzmTbVtC0WjClWi50ntMipwBClE1HOaiqk2kGXcOPsjd72xH91wlCrAcTNNjUJPgp1HnJWM4rRsuEvv4HvfYTphYTJZhkBSupTNTxnlq-LCB09YhmUDjXjNbLBtRpA-q7DUjsq3vHqRmgfSD_jDwBp3vg1liY_-9Ury-3e8vfVlLDbQ</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Ibarz Barberá, Marta</creator><creator>Morales Fernández, Laura</creator><creator>Tañá Rivero, Pedro</creator><creator>Gómez de Liaño, Rosario</creator><creator>Teus, Miguel A.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7776-504X</orcidid><orcidid>https://orcid.org/0000-0002-6182-0753</orcidid></search><sort><creationdate>202202</creationdate><title>Anterior‐segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction</title><author>Ibarz Barberá, Marta ; Morales Fernández, Laura ; Tañá Rivero, Pedro ; Gómez de Liaño, Rosario ; Teus, Miguel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-231af02e779aac3476f5218dd7ebdc61aad36c220420ee665bf03ea7f8486fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Anterior Eye Segment - diagnostic imaging</topic><topic>AS‐OCT</topic><topic>Bleb</topic><topic>Cross-Linking Reagents - administration & dosage</topic><topic>Drug Implants - administration & dosage</topic><topic>Female</topic><topic>Filtering Surgery - methods</topic><topic>Follow-Up Studies</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - diagnosis</topic><topic>Glaucoma, Open-Angle - physiopathology</topic><topic>Glaucoma, Open-Angle - therapy</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>IOP</topic><topic>Male</topic><topic>MIGS</topic><topic>Mitomycin - administration & dosage</topic><topic>Mitomycin C</topic><topic>Morphology</topic><topic>POAG</topic><topic>Postoperative Period</topic><topic>PRESERFLO</topic><topic>Pressure</topic><topic>Prospective Studies</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ibarz Barberá, Marta</creatorcontrib><creatorcontrib>Morales Fernández, Laura</creatorcontrib><creatorcontrib>Tañá Rivero, Pedro</creatorcontrib><creatorcontrib>Gómez de Liaño, Rosario</creatorcontrib><creatorcontrib>Teus, Miguel A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ibarz Barberá, Marta</au><au>Morales Fernández, Laura</au><au>Tañá Rivero, Pedro</au><au>Gómez de Liaño, Rosario</au><au>Teus, Miguel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anterior‐segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2022-02</date><risdate>2022</risdate><volume>100</volume><issue>1</issue><spage>e192</spage><epage>e203</epage><pages>e192-e203</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To analyse the morphological evolution of filtering blebs with anterior‐segment OCT (AS‐OCT) and its correlation with intraocular pressure after ab externo SIBS microshunt implantation with mitomycin C (MMC) during a 3‐month follow‐up period.
Methods
Twenty‐eight filtering blebs of 28 patients with open‐angle glaucoma were measured horizontally and vertically in the sub‐Tenon space with AS‐OCT after ab externo SIBS microshunt implantation with MMC. The intraocular pressure (IOP) was monitored simultaneously at each visit. Maturation of and morphological changes in the blebs and correlations with the IOP were recorded.
Results
The average median preoperative IOP of 20.7 (range, 12–30) mmHg decreased to 8.5 (range, 4–17), 8.9 (range, 5–17), 10.4 (range, 8–16) and 10.9 (range, 9–15) mmHg at 24 hr, 1 week, 1 month and 3 months, respectively (p < 0.001). A multiform morphology on AS‐OCT prevailed at all time points, with a 3.5% rate of a uniform bleb morphology at the first week. The horizontal and vertical diameters of the blebs increased from baseline to the third month. The horizontal expansion (406 ± 127 μm on day 7, p = 0.04, 712 ± 211 μm on day 30, p = 0.02 and 952 ± 218 μm on day 90, p < 0.001) was greater than the vertical expansion (16 ± 18 μm, p = 0.3 on day 1, 63 ± 27 μm, p = 0.02 on day 30 and 137 ± 34 μm, p < 0.001 on day 90) without correlation with the IOP (r = −0.3, p = 0.2).
Conclusion
Anterior‐segment OCT (AS‐OCT) of the filtering blebs formed after ab externo SIBS microshunt implantation showed progressive horizontal and vertical expansion of the blebs in the sub‐Tenon space, with a significant peak at the first month not significantly correlated with the decrease in the IOP.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33838021</pmid><doi>10.1111/aos.14863</doi><tpages>203</tpages><orcidid>https://orcid.org/0000-0002-7776-504X</orcidid><orcidid>https://orcid.org/0000-0002-6182-0753</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Anterior Eye Segment - diagnostic imaging AS‐OCT Bleb Cross-Linking Reagents - administration & dosage Drug Implants - administration & dosage Female Filtering Surgery - methods Follow-Up Studies Glaucoma Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - physiopathology Glaucoma, Open-Angle - therapy Humans Intraocular Pressure - physiology IOP Male MIGS Mitomycin - administration & dosage Mitomycin C Morphology POAG Postoperative Period PRESERFLO Pressure Prospective Studies Tomography, Optical Coherence - methods |
| title | Anterior‐segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction |
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