Pro- and anti-inflammatory adipokines are associated with cardiometabolic risk markers in Brazilian schoolchildren

• Published in: European journal of pediatrics 2021-09, Vol.180 (9), p.2931-2941
• Main Authors: Filgueiras, Mariana De Santis, Pessoa, Milene Cristine, Bressan, Josefina, de Albuquerque, Fernanda Martins, Suhett, Lara Gomes, Silva, Mariane Alves, de Novaes, Juliana Farias
• Format: Article
• Language: English
• Subjects: Adiponectin; Blood pressure; Children; Cholesterol; Glucose; Inflammation; Insulin resistance; Leptin; Medicine; Medicine & Public Health; Metabolic disorders; Original Article; Pediatrics; Proteins; Retinol-binding protein; Standard deviation; Vitamin A
• ISSN: 0340-6199; 1432-1076
• DOI: 10.1007/s00431-021-04040-z

Pro- and anti-inflammatory adipokines have been regarded as potential markers of obesity and cardiometabolic comorbidities. However, few studies have evaluated this association in children. We aimed to evaluate the relationship between adipokine concentrations and cardiometabolic risk markers in Brazilian schoolchildren. This was a cross-sectional study with 378 children aged 8–9 years from Viçosa, Minas Gerais, Brazil. We measured adipokines (leptin, retinol-binding protein 4, adiponectin, and chemerin) and cardiometabolic risk markers (fasting glucose, HOMA-IR, lipid profile, and blood pressure). Cardiometabolic risk markers were compared by quintiles of adipokines with linear regression adjusted for potential confounders. Leptin was positively associated with diastolic blood pressure ( P = 0.03) and HOMA-IR ( P = 0.01), and retinol-binding protein 4 was positively associated with total cholesterol ( P = 0.04). Each standard deviation of leptin and retinol-binding protein 4 was associated to, respectively, a 0.1 (95%CI: 0.1; 0.2), 0.3 (95%CI: 0.1; 0.6), and 2.5 (95%CI: 0.1; 4.9) units increase in diastolic blood pressure, HOMA-IR, and total cholesterol. Adiponectin was negatively associated with diastolic blood pressure ( P = 0.01) and HOMA-IR ( P = 0.01), and chemerin was negatively associated with glucose ( P = 0.001). Each standard deviation of adiponectin and chemerin was associated to, respectively, a −0.1 (95%CI: −0.2; −0.1), −0.2 (95%CI: −0.3; −0.1), and −1.2 (95%CI: −1.9; −0.5) units decrease in diastolic blood pressure, HOMA-IR, and glucose. Conclusion : Pro- and anti-inflammatory adipokines were positively and negatively associated with cardiometabolic risk markers, respectively, among schoolchildren, indicating this relationship may be identified at earlier ages. What is Known: • Although leptin, retinol-binding protein 4, and adiponectin are well-known adipokines, a consensus regarding their relationship with cardiometabolic risk markers, especially in schoolchildren, has not yet been reached. • Chemerin is an adipokine that has been studied recently. Yet, due to its dependence on the target cell type, its functions are still a controversial topic . What is New: • Leptin was positively associated with diastolic blood pressure and HOMA-IR, and retinol-binding protein 4 was positively associated with total cholesterol. • Adiponectin was negatively associated with diastolic blood pressure and HOMA-IR, and chemerin was negatively associated with