Revisiting dopamine-acetylcholine imbalance in Parkinson's disease: Glutamate co-transmission as an exciting partner in crime

Striatal dopamine and acetylcholine are thought to be imbalanced in Parkinson's disease. In this issue of Neuron, Cai et al. report that restoration of nigral glutamate co-transmission, acting on dorsolateral striatal cholinergic interneuron mGluR1s, can rescue motor dysfunction in a mouse mode...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2021-04, Vol.109 (7), p.1070-1071
Main Authors: Zhang, Yan-Feng, Cragg, Stephanie J
Format: Article
Language:English
Subjects:
Acetylcholine
Animals
Cholinergic Agents
Corpus Striatum
Crime
Disease transmission
Dopamine
Glutamic Acid
Glutamic acid receptors (metabotropic)
Interneurons
Mice
Motor Disorders
Movement disorders
Neostriatum
Neurodegenerative diseases
Neurons
Parkinson Disease
Parkinson's disease
Substantia nigra
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Summary:Striatal dopamine and acetylcholine are thought to be imbalanced in Parkinson's disease. In this issue of Neuron, Cai et al. report that restoration of nigral glutamate co-transmission, acting on dorsolateral striatal cholinergic interneuron mGluR1s, can rescue motor dysfunction in a mouse model of Parkinson's.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2021.03.018