Klotho Protein and Cardio-Vascular System

Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels an...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2021-02, Vol.86 (2), p.132-145
Main Authors: Tyurenkov, Ivan N., Perfilova, Valentina N., Nesterova, Alla A., Glinka, Yelena
Format: Article
Language:English
Subjects:
Amino acids
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Blood circulation disorders
Blood vessels
Calcification
Fibrosis
Health aspects
Inflammation
Injury prevention
Ion channels
Klotho protein
Life Sciences
Lipid peroxidation
Lipids
Low level
Metabolic pathways
Microbiology
Pathogenesis
Peroxidation
Proteins
Review
Rigidity
Vascular diseases
Vascular system
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Summary:Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels and suppresses development of the heart fibrosis. Low level of its expression is associated with a number of diseases. Cardioprotective effect of klotho is based on its ability to interact with multiple receptors and ion channels. Being a pleiotropic protein, klotho could be a useful target for therapeutic intervention in the treatment of cardio-vascular diseases. In this review we present data on pharmaceuticals that stimulate klotho expression and suggest some promising research directions.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297921020024