Klotho Protein and Cardio-Vascular System

Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels an...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry (Moscow) 2021-02, Vol.86 (2), p.132-145
Main Authors: Tyurenkov, Ivan N., Perfilova, Valentina N., Nesterova, Alla A., Glinka, Yelena
Format: Article
Language:English
Subjects:
Amino acids
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Blood circulation disorders
Blood vessels
Calcification
Fibrosis
Health aspects
Inflammation
Injury prevention
Ion channels
Klotho protein
Life Sciences
Lipid peroxidation
Lipids
Low level
Metabolic pathways
Microbiology
Pathogenesis
Peroxidation
Proteins
Review
Rigidity
Vascular diseases
Vascular system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c487t-49654797627be204d6f06a7199631d751eaf734938603eee7ef3f7097e55c44b3
cites cdi_FETCH-LOGICAL-c487t-49654797627be204d6f06a7199631d751eaf734938603eee7ef3f7097e55c44b3
container_end_page 145
container_issue 2
container_start_page 132
container_title Biochemistry (Moscow)
container_volume 86
creator Tyurenkov, Ivan N.
Perfilova, Valentina N.
Nesterova, Alla A.
Glinka, Yelena
description Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels and suppresses development of the heart fibrosis. Low level of its expression is associated with a number of diseases. Cardioprotective effect of klotho is based on its ability to interact with multiple receptors and ion channels. Being a pleiotropic protein, klotho could be a useful target for therapeutic intervention in the treatment of cardio-vascular diseases. In this review we present data on pharmaceuticals that stimulate klotho expression and suggest some promising research directions.
doi_str_mv 10.1134/S0006297921020024
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2511240713</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A652582244</galeid><sourcerecordid>A652582244</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-49654797627be204d6f06a7199631d751eaf734938603eee7ef3f7097e55c44b3</originalsourceid><addsrcrecordid>eNp1kUtLxDAUhYMoOj5-gBsZcKOL6s27WcrgCwWFUbch095qpW00aRf-ezPMqPgii5B7vnO44RCyS-GIUi6OpwCgmNGGUWAATKyQEVWQZxwErJLRXM7m-gbZjPE5PRkYvk42OM85E5SNyOFV4_snP74Nvse6G7uuHE9cKGufPbhYDI0L4-lb7LHdJmuVayLuLO8tcn92eje5yK5vzi8nJ9dZIXLdZ8IoKbTRiukZMhClqkA5TY1RnJZaUnSV5sLwXAFHRI0VrzQYjVIWQsz4FjlY5L4E_zpg7G1bxwKbxnXoh2iZpJQJ0JQndP8H-uyH0KXtLBOGKi5ByS_q0TVo667yfXDFPNSeKMlkzpgQiTr6g0qnxLYufIdVnebfDHRhKIKPMWBlX0LduvBmKdh5PfZXPcmzt1x4mLVYfjo--kgAWwAxSd0jhq8f_Z_6Dmd7k2k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2491635065</pqid></control><display><type>article</type><title>Klotho Protein and Cardio-Vascular System</title><source>Springer Nature</source><creator>Tyurenkov, Ivan N. ; Perfilova, Valentina N. ; Nesterova, Alla A. ; Glinka, Yelena</creator><creatorcontrib>Tyurenkov, Ivan N. ; Perfilova, Valentina N. ; Nesterova, Alla A. ; Glinka, Yelena</creatorcontrib><description>Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels and suppresses development of the heart fibrosis. Low level of its expression is associated with a number of diseases. Cardioprotective effect of klotho is based on its ability to interact with multiple receptors and ion channels. Being a pleiotropic protein, klotho could be a useful target for therapeutic intervention in the treatment of cardio-vascular diseases. In this review we present data on pharmaceuticals that stimulate klotho expression and suggest some promising research directions.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297921020024</identifier><identifier>PMID: 33832412</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Amino acids ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Blood circulation disorders ; Blood vessels ; Calcification ; Fibrosis ; Health aspects ; Inflammation ; Injury prevention ; Ion channels ; Klotho protein ; Life Sciences ; Lipid peroxidation ; Lipids ; Low level ; Metabolic pathways ; Microbiology ; Pathogenesis ; Peroxidation ; Proteins ; Review ; Rigidity ; Vascular diseases ; Vascular system</subject><ispartof>Biochemistry (Moscow), 2021-02, Vol.86 (2), p.132-145</ispartof><rights>Pleiades Publishing, Ltd. 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Pleiades Publishing, Ltd. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-49654797627be204d6f06a7199631d751eaf734938603eee7ef3f7097e55c44b3</citedby><cites>FETCH-LOGICAL-c487t-49654797627be204d6f06a7199631d751eaf734938603eee7ef3f7097e55c44b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33832412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tyurenkov, Ivan N.</creatorcontrib><creatorcontrib>Perfilova, Valentina N.</creatorcontrib><creatorcontrib>Nesterova, Alla A.</creatorcontrib><creatorcontrib>Glinka, Yelena</creatorcontrib><title>Klotho Protein and Cardio-Vascular System</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels and suppresses development of the heart fibrosis. Low level of its expression is associated with a number of diseases. Cardioprotective effect of klotho is based on its ability to interact with multiple receptors and ion channels. Being a pleiotropic protein, klotho could be a useful target for therapeutic intervention in the treatment of cardio-vascular diseases. In this review we present data on pharmaceuticals that stimulate klotho expression and suggest some promising research directions.</description><subject>Amino acids</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Blood circulation disorders</subject><subject>Blood vessels</subject><subject>Calcification</subject><subject>Fibrosis</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Injury prevention</subject><subject>Ion channels</subject><subject>Klotho protein</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Low level</subject><subject>Metabolic pathways</subject><subject>Microbiology</subject><subject>Pathogenesis</subject><subject>Peroxidation</subject><subject>Proteins</subject><subject>Review</subject><subject>Rigidity</subject><subject>Vascular diseases</subject><subject>Vascular system</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kUtLxDAUhYMoOj5-gBsZcKOL6s27WcrgCwWFUbch095qpW00aRf-ezPMqPgii5B7vnO44RCyS-GIUi6OpwCgmNGGUWAATKyQEVWQZxwErJLRXM7m-gbZjPE5PRkYvk42OM85E5SNyOFV4_snP74Nvse6G7uuHE9cKGufPbhYDI0L4-lb7LHdJmuVayLuLO8tcn92eje5yK5vzi8nJ9dZIXLdZ8IoKbTRiukZMhClqkA5TY1RnJZaUnSV5sLwXAFHRI0VrzQYjVIWQsz4FjlY5L4E_zpg7G1bxwKbxnXoh2iZpJQJ0JQndP8H-uyH0KXtLBOGKi5ByS_q0TVo667yfXDFPNSeKMlkzpgQiTr6g0qnxLYufIdVnebfDHRhKIKPMWBlX0LduvBmKdh5PfZXPcmzt1x4mLVYfjo--kgAWwAxSd0jhq8f_Z_6Dmd7k2k</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Tyurenkov, Ivan N.</creator><creator>Perfilova, Valentina N.</creator><creator>Nesterova, Alla A.</creator><creator>Glinka, Yelena</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210201</creationdate><title>Klotho Protein and Cardio-Vascular System</title><author>Tyurenkov, Ivan N. ; Perfilova, Valentina N. ; Nesterova, Alla A. ; Glinka, Yelena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-49654797627be204d6f06a7199631d751eaf734938603eee7ef3f7097e55c44b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amino acids</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Blood circulation disorders</topic><topic>Blood vessels</topic><topic>Calcification</topic><topic>Fibrosis</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Injury prevention</topic><topic>Ion channels</topic><topic>Klotho protein</topic><topic>Life Sciences</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Low level</topic><topic>Metabolic pathways</topic><topic>Microbiology</topic><topic>Pathogenesis</topic><topic>Peroxidation</topic><topic>Proteins</topic><topic>Review</topic><topic>Rigidity</topic><topic>Vascular diseases</topic><topic>Vascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tyurenkov, Ivan N.</creatorcontrib><creatorcontrib>Perfilova, Valentina N.</creatorcontrib><creatorcontrib>Nesterova, Alla A.</creatorcontrib><creatorcontrib>Glinka, Yelena</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemistry (Moscow)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tyurenkov, Ivan N.</au><au>Perfilova, Valentina N.</au><au>Nesterova, Alla A.</au><au>Glinka, Yelena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Klotho Protein and Cardio-Vascular System</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>86</volume><issue>2</issue><spage>132</spage><epage>145</epage><pages>132-145</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>Klotho protein affects a number of metabolic pathways essential for pathogenesis of cardio-vascular diseases and their prevention. It inhibits lipid peroxidation and inflammation, as well as prevents endothelial injury and calcification of blood vessels. Klotho decreases rigidity of blood vessels and suppresses development of the heart fibrosis. Low level of its expression is associated with a number of diseases. Cardioprotective effect of klotho is based on its ability to interact with multiple receptors and ion channels. Being a pleiotropic protein, klotho could be a useful target for therapeutic intervention in the treatment of cardio-vascular diseases. In this review we present data on pharmaceuticals that stimulate klotho expression and suggest some promising research directions.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>33832412</pmid><doi>10.1134/S0006297921020024</doi><tpages>14</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0006-2979
ispartof Biochemistry (Moscow), 2021-02, Vol.86 (2), p.132-145
issn 0006-2979
1608-3040
language eng
recordid cdi_proquest_miscellaneous_2511240713
source Springer Nature
subjects Amino acids
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Blood circulation disorders
Blood vessels
Calcification
Fibrosis
Health aspects
Inflammation
Injury prevention
Ion channels
Klotho protein
Life Sciences
Lipid peroxidation
Lipids
Low level
Metabolic pathways
Microbiology
Pathogenesis
Peroxidation
Proteins
Review
Rigidity
Vascular diseases
Vascular system
title Klotho Protein and Cardio-Vascular System
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T16%3A37%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Klotho%20Protein%20and%20Cardio-Vascular%20System&rft.jtitle=Biochemistry%20(Moscow)&rft.au=Tyurenkov,%20Ivan%20N.&rft.date=2021-02-01&rft.volume=86&rft.issue=2&rft.spage=132&rft.epage=145&rft.pages=132-145&rft.issn=0006-2979&rft.eissn=1608-3040&rft_id=info:doi/10.1134/S0006297921020024&rft_dat=%3Cgale_proqu%3EA652582244%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c487t-49654797627be204d6f06a7199631d751eaf734938603eee7ef3f7097e55c44b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2491635065&rft_id=info:pmid/33832412&rft_galeid=A652582244&rfr_iscdi=true