Rutin Improves Cardiac and Erythrocyte Membrane–Bound ATPase Activities in Male Rats Exposed to Cadmium Chloride and Lead Acetate

• Published in: Biological trace element research 2022-03, Vol.200 (3), p.1181-1189
• Main Authors: Oluranti, Olufemi I., Adeyemo, Victor A., Achile, Esther O., Fatokun, Bosede P., Ojo, Alaba O.
• Format: Article
• Language: English
• Subjects: Acetates; Animals; Biochemistry; Biomedical and Life Sciences; Biotechnology; Ca2+-transporting ATPase; Cadmium; Cadmium - toxicity; Cadmium chloride; Cadmium Chloride - toxicity; Calcium; Calcium ions; Cardiovascular diseases; Disorders; Erythrocyte Membrane - metabolism; Erythrocytes; Heart; Lead; Lead - toxicity; Lead acetates; Life Sciences; Male; Males; Membranes; Na+/K+-exchanging ATPase; Nutrition; Oncology; Rats; Rats, Wistar; Rodents; Rutin; Rutin - pharmacology; Sodium-Potassium-Exchanging ATPase - metabolism
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-021-02711-4

Cardiovascular diseases have been associated with cadmium (Cd) and lead (Pb). Impaired Ca 2+ and Na + /K + -ATPase activities have also been linked to hemolytic and cardiovascular disorders. This study investigated the effect of rutin on Cd and/or Pb-induced cardiac and erythrocyte disorders in male rats. Twenty-five (25) male Wistar rats were treated as ( n =5): Control, Pb (60 mg/kg, p.o ), Cd (5 mg/kg, p.o ), Pb + Cd, Rutin + Pb + Cd (50 mg/kg Rt, 60 mg/kg Pb, 5 mg/kg Cd, p.o ). Plasma electrolyte and Ca 2+ - and Na + /K + -ATPase activities in the erythrocyte and heart of the rats were assayed. There was an increased and decreased activity of cardiac and erythrocyte Na + /K + -ATPase in Pb- (172%) and Cd- (33.7%) treated groups, respectively. However, rutin increased erythrocyte Na + /K + -ATPase activity in Cd + Pb when compared with Cd and Cd + Pb groups. Erythrocyte Ca 2+ -ATPase activity was decreased in the Pb (68%), Cd (68%) and Cd + Pb (55.3%) groups. Cardiac Na + /K + -ATPase activity was not altered in Pb and Cd groups while it decreased in Cd + Pb. Rutin increased the activity of the pump in Cd +Pb-treated rats compared to the Cd+Pb group. Therefore, rutin reversed cadmium- and lead-induced impaired cardiac and erythrocyte membrane Ca 2+ - and Na + /K + -ATPase activities. Graphical Abstract Dotted lines—decrease activity, curved lines—increased activity (created with BioRender.com )