Lipoxins and synthetic lipoxin mimetics: Therapeutic potential in renal diseases

Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory the...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular and cell biology of lipids 2021-08, Vol.1866 (8), p.158940, Article 158940
Main Authors: Andrews, Darrell, Godson, Catherine
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
AT-01-KG
Cellular plasticity
Fibrosis
Humans
Inflammation - drug therapy
Inflammation - metabolism
Kidney Diseases - drug therapy
Kidney Diseases - metabolism
Lipoxins
Lipoxins - metabolism
Lipoxins - pharmacology
Lipoxins - therapeutic use
Renal inflammation
Resolution of inflammation
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Summary:Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics. However, these are associated with undesirable side effects including immune suppression. More recently, there is growing appreciation that specialized lipid mediators [SPMs] including lipoxins promote the resolution of inflammation and endogenous repair mechanisms without compromising host defence. We discuss the pro-resolving bioactions of lipoxins and recent work that aims to harness their therapeutic potential in the context of kidney disease.
ISSN:1388-1981
1879-2618
1879-2618
DOI:10.1016/j.bbalip.2021.158940