Systemic inflammation mediates the negative relationship between visceral adiposity and cognitive control

Elevated visceral adipose tissue (VAT) has been associated with cardiometabolic risk factors including chronic systemic low-grade inflammation. Whereas the cognitive implications of inflammation have been extensively studied in preclinical models, the influence of inflammatory cytokines on cognitive...

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Bibliographic Details
Published in:International journal of psychophysiology 2021-07, Vol.165, p.68-75
Main Authors: Cannavale, Corinne N., Bailey, Melisa, Edwards, Caitlyn G., Thompson, Sharon V., Walk, Anne M., Burd, Nicholas A., Holscher, Hannah D., Khan, Naiman A.
Format: Article
Language:English
Subjects:
C-reactive protein
Cognition
Flanker
Inflammation
Interleukin-6
Obesity
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Summary:Elevated visceral adipose tissue (VAT) has been associated with cardiometabolic risk factors including chronic systemic low-grade inflammation. Whereas the cognitive implications of inflammation have been extensively studied in preclinical models, the influence of inflammatory cytokines on cognitive function in humans is unclear. This study aimed to investigate the relations among VAT, inflammatory cytokines, and cognitive control. We hypothesized that inflammatory markers would mediate the negative influence of VAT on selective attention. Participants between 25 and 46 years (N = 115, 43 females) underwent a DXA scan to estimate VAT. A modified Eriksen Flanker task was used to assess attentional inhibitory control while event-related potentials were recorded. ELISA was used to quantify plasma C-reactive protein (CRP) and Interleukin-6 (IL-6) concentrations. Mediation modeling while controlling for diet quality and education level revealed that CRP concentrations significantly mediated the relationship between VAT and incongruent trial accuracy (indirect effect 95% CI {−0.24, −0.01}). Further, IL-6 concentrations had a significant mediation effect on the relationship between VAT and incongruent P3 peak latency (indirect effect 95% CI {0.05, 1.39}). These results suggest that mechanisms by which visceral adiposity exerts a negative influence on cognitive function includes systemic inflammation. •Visceral adipose and systemic inflammation are related to poorer attentional control and neuroelectric function•C-reactive protein mediates the relationship between visceral adiposity and attentional control•Interleukin-6 mediates the relationship between visceral adiposity and neuroelectric attentional processing speed
ISSN:0167-8760
1872-7697
DOI:10.1016/j.ijpsycho.2021.03.010