High-fructose diet-induced hepatic expression of the Scd1 gene is associated with increased acetylation of histones H3 and H4 and the binding of ChREBP at the Scd1 promoter in rats

Stearoyl-CoA desaturase-1 (SCD1) is a key enzyme in the biosynthesis of monounsaturated fatty acids, and the expression of the Scd1 gene is induced by the intake of the lipogenic sugar fructose. We examined the effects of a high-fructose diet on hepatic acetylation of histones H3 and H4 and the bind...

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Bibliographic Details
Published in:Biomedical Research 2021/04/10, Vol.42(2), pp.85-88
Main Authors: SHIMADA, Masaya, HIBI, Mayu, NAKAGAWA, Tomoyuki, HAYAKAWA, Takashi, FIELD, Catherine J.
Format: Article
Language:English
Subjects:
Acetylation
Animal Feed
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - biosynthesis
Biosynthesis
Carbohydrates
Desaturase
Diet
Fatty acids
Fructose
Fructose - chemistry
Gene expression
Gene Expression Regulation
Histone H3
Histones
Histones - metabolism
Liver
Liver - metabolism
Male
Promoter Regions, Genetic
Protein Binding
Protein Processing, Post-Translational
Rats
Rats, Wistar
Scd1 protein
Stearoyl-CoA desaturase
Stearoyl-CoA Desaturase - biosynthesis
Stearoyl-CoA Desaturase - genetics
Triglycerides
Triglycerides - metabolism
Up-Regulation
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Summary:Stearoyl-CoA desaturase-1 (SCD1) is a key enzyme in the biosynthesis of monounsaturated fatty acids, and the expression of the Scd1 gene is induced by the intake of the lipogenic sugar fructose. We examined the effects of a high-fructose diet on hepatic acetylation of histones H3 and H4 and the binding of carbohydrate response element-binding protein (ChREBP) on the Scd1 gene promoter in rats. Rats were fed a control diet or a high-fructose diet for 10 days. The intake of a high-fructose diet significantly increased histone H3 and H4 acetylation and ChREBP binding to the Scd1 gene promoter as well as the amount of triglyceride and the expression of the Scd1 gene. These results suggest that short-term intake of high fructose upregulates expression of Scd1 by enhancing acetylation of histones H3 and H4 and binding of ChREBP at the Scd1 promoter.
ISSN:0388-6107
1880-313X
DOI:10.2220/biomedres.42.85